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Scientific article
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English

To Balloon or Not to Balloon? The Effects of an Intra-Aortic Balloon-Pump on Coronary Artery Flow during Extracorporeal Circulation Simulating Normal and Low Cardiac Output Syndromes

Published inJournal of clinical medicine, vol. 10, no. 22, 5333
Publication date2021-11-16
First online date2021-11-16
Abstract

ECMO is the most frequently used mechanical support for patients suffering from low cardiac output syndrome. Combining IABP with ECMO is believed to increase coronary artery blood flow, decrease high afterload, and restore systemic pulsatile flow conditions. This study evaluates that combined effect on coronary artery flow during various load conditions using an in vitro circuit. In doing so, different clinical scenarios were simulated, such as normal cardiac output and moderate-to-severe heart failure. In the heart failure scenarios, we used peripheral ECMO support to compensate for the lowered cardiac output value and reach a default normal value. The increase in coronary blood flow using the combined IABP-ECMO setup was more noticeable in low heart rate conditions. At baseline, intermediate and severe LV failure levels, adding IABP increased coronary mean flow by 16%, 7.5%, and 3.4% (HR 60 bpm) and by 6%, 4.5%, and 2.5% (HR 100 bpm) respectively. Based on our in vitro study results, combining ECMO and IABP in a heart failure setup further improves coronary blood flow. This effect was more pronounced at a lower heart rate and decreased with heart failure, which might positively impact recovery from cardiac failure.

eng
Keywords
  • ECMO
  • IABP
  • Coronary blood flow
  • In vitro mock-up circuit
  • Low cardiac output syndrome
Citation (ISO format)
REYMOND, Philippe et al. To Balloon or Not to Balloon? The Effects of an Intra-Aortic Balloon-Pump on Coronary Artery Flow during Extracorporeal Circulation Simulating Normal and Low Cardiac Output Syndromes. In: Journal of clinical medicine, 2021, vol. 10, n° 22, p. 5333. doi: 10.3390/jcm10225333
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Article (Published version)
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ISSN of the journal2077-0383
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Technical informations

Creation12/02/2021 12:42:00 PM
First validation12/02/2021 12:42:00 PM
Update time10/04/2023 7:34:52 AM
Status update10/04/2023 7:34:52 AM
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