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Scientific article
Open access
English

Long-term outcome of patients with spinal myxopapillary ependymoma: treatment results from the MD Anderson Cancer Center and institutions from the Rare Cancer Network

Published inNeuro-oncology, vol. 17, no. 4, p. 588-595
Publication date2015-04
First online date2014-10-09
Abstract

Background: Spinal myxopapillary ependymomas (MPEs) are slowly growing ependymal gliomas with preferential manifestation in young adults. The aim of this study was to assess the outcome of patients with MPE treated with surgery, radiotherapy (RT), and/or chemotherapy.

Methods: The medical records of 183 MPE patients (male: 59%) treated at the MD Anderson Cancer Center and 11 institutions from the Rare Cancer Network were retrospectively reviewed. Mean patient' age at diagnosis was 35.5 ± 15.8 years. Ninety-seven (53.0%) patients underwent surgery without RT, and 86 (47.0%) were treated with surgery and/or RT. Median RT dose was 50.4 Gy. Median follow-up was 83.9 months.

Results: Fifteen (8.2%) patients died, 7 of unrelated cause. The estimated 10-year overall survival was 92.4% (95% CI: 87.7-97.1). Treatment failure was observed in 58 (31.7%) patients. Local failure, distant spinal relapse, and brain failure were observed in 49 (26.8%), 17 (9.3%), and 11 (6.0%) patients, respectively. The estimated 10-year progression-free survival was 61.2% (95% CI: 52.8-69.6). Age (<36 vs ≥36 y), treatment modality (surgery alone vs surgery and RT), and extent of surgery were prognostic factors for local control and progression-free survival on univariate and multivariate analysis.

Conclusions: In this series, treatment failure of MPE occurred in approximately one third of patients. The observed recurrence pattern of primary spinal MPE was mainly local, but a substantial number of patients failed nonlocally. Younger patients and those not treated initially with adjuvant RT or not undergoing gross total resection were significantly more likely to present with tumor recurrence/progression.

eng
Keywords
  • Myxopapillary ependymoma
  • Radiotherapy
  • Spinal failures
  • Spinal tumors
  • Adult
  • Chemotherapy, Adjuvant
  • Disease-Free Survival
  • Ependymoma / drug therapy
  • Ependymoma / radiotherapy
  • Ependymoma / surgery
  • Ependymoma / therapy
  • Female
  • Humans
  • Male
  • Spinal Neoplasms / drug therapy
  • Spinal Neoplasms / radiotherapy
  • Spinal Neoplasms / surgery
  • Spinal Neoplasms / therapy
  • Treatment Outcome
Citation (ISO format)
WEBER, Damien C. et al. Long-term outcome of patients with spinal myxopapillary ependymoma: treatment results from the MD Anderson Cancer Center and institutions from the Rare Cancer Network. In: Neuro-oncology, 2015, vol. 17, n° 4, p. 588–595. doi: 10.1093/neuonc/nou293
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1522-8517
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