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Rôle du néphron distal dans le contrôle du volume extracellulaire en condition physiologique et dans le syndrome néphrotique

Published inMS. Médecine sciences, vol. 37, no. 4, p. 359-365
Publication date2021-04-28
First online date2021-04-28
Abstract

The kidney plays a major role to maintain the constancy of the "milieu intérieur" by adjusting the urinary excretion of water and solutes to the requirement of the body balance. This function is coordinated with elimination of waste products generated among others by the catabolism of proteins and nucleic acids. To cope with these two major functions, the human kidneys generate each day about 180 L of ultrafiltrate from plasma and reabsorbs the vast majority of filtered water and solutes to excrete daily about one-two liter(s) of urine containing concentrations of sodium, potassium and chloride ranging from 20 to 200 mM. The final adjustment of urine composition is finely tuned along the aldosterone-sensitive distal nephron (ASDN) which includes the distal convoluted tubule and the collecting system (connecting tubule and collecting duct). Sodium reabsorption is predominant along the distal tubule if potassium must be spared, or along the collecting system when large amounts of potassium must be secreted. Nephrotic syndrome is characterized by heavy proteinuria consecutive to a glomerular injury, associated with renal sodium and water retention taking initially place along ASDN and leading to edema.

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Keywords
  • Animals
  • Body Water / metabolism
  • Chlorides / metabolism
  • Humans
  • Kidney Tubules, Collecting / metabolism
  • Kidney Tubules, Distal / metabolism
  • Kidney Tubules, Proximal / metabolism
  • Loop of Henle / metabolism
  • Mice
  • Nephrons / metabolism
  • Nephrons / physiology
  • Nephrons / physiopathology
  • Nephrotic Syndrome / metabolism
  • Nephrotic Syndrome / physiopathology
  • Nucleic Acids / metabolism
  • Potassium / metabolism
  • Proteins / metabolism
  • Renin-Angiotensin System / physiology
  • Sodium / metabolism
  • Urine / chemistry
Citation (ISO format)
FERAILLE, Eric, OLIVIER, Valérie. Rôle du néphron distal dans le contrôle du volume extracellulaire en condition physiologique et dans le syndrome néphrotique. In: MS. Médecine sciences, 2021, vol. 37, n° 4, p. 359–365. doi: 10.1051/medsci/2021032
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Article (Published version)
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Identifiers
ISSN of the journal0767-0974
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Creation10/21/2021 2:10:00 PM
First validation10/21/2021 2:10:00 PM
Update time03/16/2023 2:30:20 AM
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