Very low blood flow carbon dioxide removal system is not effective in a chronic obstructive pulmonary disease exacerbation setting

Giraud, Raphaël; Banfi, Carlo; Assouline, Benjamin; de Charrière, Amandine Solange Marie; Bendjelid, Karim

doi:10.1111/aor.13867

Scientific article

English

Very low blood flow carbon dioxide removal system is not effective in a chronic obstructive pulmonary disease exacerbation setting

Contributors

Giraud, Raphaël

; Banfi, Carlo; Assouline, Benjamin; de Charrière, Amandine Solange Marie; Bendjelid, Karim

Published in

Artificial organs, vol. 45, no. 5, p. 479-487

Publication date

2021-05

First online date

2020-11-13

Abstract

Extracorporeal carbon dioxide removal (ECCO₂R) is a low blood flow veno-venous extracorporeal membrane oxygenation technique that provides artificial blood CO₂removal. Recently, a new ECCO₂R system (PrismaLung), providing very low blood flow has been commercialized. The aim of this study is to report its use in severe chronic obstructive pulmonary disease (COPD) patients needing an ECCO₂R therapy. Six severe COPD patients with acute exacerbation leading to refractory hypercapnic respiratory acidosis were treated with ECCO₂R therapy. Two different systems were used: a PrismaLung system and a conventional ECCO₂R device. The maximum blood flow provided by PrismaLung was significantly lower than that with the conventional ECCO₂R system. In three patients initially treated with PrismaLung, there were no improvements in pH, PaCO₂, or RR. Thus, the therapy was switched to a conventional ECCO₂R system in these three patients, and three others were treated from the outset by the conventional ECCO₂R system, providing significant improvement in pH, PaCO₂, and RR. The present retrospective study describes the first use of PrismaLung in severe COPD patients with acute exacerbation. When compared with a higher blood flow ECCO₂R system, our results show that this novel, very low-flow device is not able to remove sufficient CO₂, normalize pH or decrease respiratory rate.

Keywords

Chronic obstructive pulmonary disease
Extracorporeal carbon dioxide removal
Veno-venous extracorporeal membrane oxygenation

UNIGE affiliation entities

Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences

UNIGE research groups

Groupe de recherche en hémodynamique (913)

Citation (ISO format)

GIRAUD, Raphaël et al. Very low blood flow carbon dioxide removal system is not effective in a chronic obstructive pulmonary disease exacerbation setting. In: Artificial organs, 2021, vol. 45, n° 5, p. 479–487. doi: 10.1111/aor.13867

Article (Published version)

CC BY

Identifiers

PID : unige:158353
DOI : 10.1111/aor.13867
PMID : 33184873

Additional URL for this publication

https://onlinelibrary.wiley.com/doi/10.1111/aor.13867

Journal ISSN

0160-564X

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Creation

18/10/2021 17:20:00

First validation

18/10/2021 17:20:00

Update

16/03/2023 02:29:38

Status update

16/03/2023 02:29:37

Last indexation

01/11/2024 00:38:39

Very low blood flow carbon dioxide removal system is not effective in a chronic obstructive pulmonary disease exacerbation setting

Contributors

Published in

Publication date

First online date

Abstract

Keywords

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

Main files (1)

Identifiers

Additional URL for this publication

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation