en
Scientific article
Open access
English

Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa

Published inBMC medicine, vol. 16, no. 1, 11
Publication date2018-01-18
First online date2018-01-18
Abstract

In 2012, the World Health Organization recommended blocking the transmission of Plasmodium falciparum with single low-dose primaquine (SLDPQ, target dose 0.25 mg base/kg body weight), without testing for glucose-6-phosphate dehydrogenase deficiency (G6PDd), when treating patients with uncomplicated falciparum malaria. We sought to develop an age-based SLDPQ regimen that would be suitable for sub-Saharan Africa.

eng
Keywords
  • Age-based dosing
  • Malaria
  • Plasmodium falciparum
  • Primaquine
  • Transmission blocking
  • Adolescent
  • Adult
  • Africa South of the Sahara
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Antimalarials / administration & dosage
  • Antimalarials / adverse effects
  • Antimalarials / therapeutic use
  • Child
  • Child, Preschool
  • Clinical Protocols
  • Dose-Response Relationship, Drug
  • Female
  • Glucosephosphate Dehydrogenase Deficiency
  • Humans
  • Infant
  • Malaria, Falciparum / drug therapy
  • Malaria, Falciparum / prevention & control
  • Malaria, Falciparum / transmission
  • Male
  • Middle Aged
  • Plasmodium falciparum
  • Primaquine / administration & dosage
  • Primaquine / adverse effects
  • Primaquine / therapeutic use
  • Young Adult
Funding
  • Wellcome Trust - Core Support for the East African Major Overseas Programme [203077]
  • Wellcome Trust - The health consequences of genetic variants that have been selected by malaria, with a particular focus on polymorphisms affecting the red blood cell [202800]
Citation (ISO format)
TAYLOR, Walter Robert John et al. Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa. In: BMC medicine, 2018, vol. 16, n° 1, p. 11. doi: 10.1186/s12916-017-0990-6
Main files (1)
Article (Published version)
Secondary files (2)
Identifiers
ISSN of the journal1741-7015
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