Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa

Taylor, Walter Robert John; Naw, Htee Khu; Maitland, Kathryn; Williams, Thomas N; Kapulu, Melissa; D'Alessandro, Umberto; Berkley, James A; Bejon, Philip; Okebe, Joseph; Achan, Jane; Amambua, Alfred Ngwa; Affara, Muna; Nwakanma, Davis; van Geertruyden, Jean-Pierre; Mavoko, Muhindo; Lutumba, Pascal; Matangila, Junior; Brasseur, Philipe; Piola, Patrice; Randremanana, Rindra; Lasry, Estrella; Fanello, Caterina; Onyamboko, Marie; Schramm, Birgit; Yah, Zolia; Jones, Joel; Fairhurst, Rick M; Diakite, Mahamadou; Malenga, Grace; Molyneux, Malcolm; Rwagacondo, Claude; Obonyo, Charles; Gadisa, Endalamaw; Aseffa, Abraham; Loolpapit, Mores; Henry, Marie-Claire; Dorsey, Grant; John, Chandy; Sirima, Sodiomon B; Barnes, Karen I; Kremsner, Peter; Day, Nicholas P; White, Nicholas J; Mukaka, Mavuto

doi:10.1186/s12916-017-0990-6

Scientific article

English

Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa

Published inBMC medicine, vol. 16, no. 1, 11

Publication date2018-01-18

First online date2018-01-18

Abstract

In 2012, the World Health Organization recommended blocking the transmission of Plasmodium falciparum with single low-dose primaquine (SLDPQ, target dose 0.25 mg base/kg body weight), without testing for glucose-6-phosphate dehydrogenase deficiency (G6PDd), when treating patients with uncomplicated falciparum malaria. We sought to develop an age-based SLDPQ regimen that would be suitable for sub-Saharan Africa.

Keywords

Age-based dosing
Malaria
Plasmodium falciparum
Primaquine
Transmission blocking
Adolescent
Adult
Africa South of the Sahara
Age Factors
Aged
Aged, 80 and over
Antimalarials / administration & dosage
Antimalarials / adverse effects
Antimalarials / therapeutic use
Child
Child, Preschool
Clinical Protocols
Dose-Response Relationship, Drug
Female
Glucosephosphate Dehydrogenase Deficiency
Humans
Infant
Malaria, Falciparum / drug therapy
Malaria, Falciparum / prevention & control
Malaria, Falciparum / transmission
Male
Middle Aged
Plasmodium falciparum
Primaquine / administration & dosage
Primaquine / adverse effects
Primaquine / therapeutic use
Young Adult

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires

Funding

Wellcome Trust - Core Support for the East African Major Overseas Programme [203077]
Wellcome Trust - The health consequences of genetic variants that have been selected by malaria, with a particular focus on polymorphisms affecting the red blood cell [202800]

Citation (ISO format)

TAYLOR, Walter Robert John et al. Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa. In: BMC medicine, 2018, vol. 16, n° 1, p. 11. doi: 10.1186/s12916-017-0990-6