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Scientific article
Open access
English

Histological transformation in recurrent WHO grade I meningiomas

Published inScientific Reports, vol. 10, no. 1, 11220
Publication date2020
Abstract

Atypical or malignant transformation (AT/MT) has been described in WHO grade I meningiomas. Our aim was to identify predictive factors of AT/MT at recurrence. A total of N = 15 WHO grade increases were observed in N = 13 patients (0.96% of the study population, risk of transformation of 0.12% per patient-year follow-up). Patients with and without progression at recurrence were similar regarding age, gender distribution, skull-base location, bone infiltration, and Simpson grades. Recurrence-free survival was lower in patients with transformation (5 ± 4.06 years versus 7.3 ± 5.4 years; p = 0.03). Among patient age, gender, skull base location, extent of resection or post-operative RT, no predictor of AT/MT was identified, despite a follow-up of 10,524 patient-years. The annual risk of transformation of WHO grade I meningiomas was 0.12% per patient-year follow-up. Despite the important number of patients included and their extended follow-up, we did not identify any risk factor for transformation. A total of 1,352 patients with surgically managed WHO grade I meningioma from a mixed retro-and prospective database with mean follow-up of 9.2 years ± 5.7 years (0.3-20.9 years) were reviewed. Recurring tumors at the site of initial surgery were considered as recurrence.

Keywords
  • Adult
  • Aftercare
  • Aged
  • Disease Progression
  • Disease-Free Survival
  • Female
  • Humans
  • Male
  • Meningeal Neoplasms/diagnosis/mortality/pathology/therapy
  • Meninges/pathology/surgery
  • Meningioma/diagnosis/mortality/pathology/therapy
  • Middle Aged
  • Neoplasm Grading
  • Neoplasm Recurrence
  • Local/diagnosis/epidemiology/pathology/prevention & control
  • Neurosurgical Procedures
  • Radiotherapy
  • Adjuvant
  • Retrospective Studies
  • Risk Factors
Citation (ISO format)
CORNIOLA, Marco, LEMÉE, Jean-Michel, MELING, Torstein. Histological transformation in recurrent WHO grade I meningiomas. In: Scientific Reports, 2020, vol. 10, n° 1, p. 11220. doi: 10.1038/s41598-020-68177-x
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Article (Published version)
Identifiers
ISSN of the journal2045-2322
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Creation10/19/2021 10:42:00 AM
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