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Privat-docent thesis
English

Is the Intracrinology of Endometriosis Relevant in Clinical Practice?

Contributors

Pluchino, Nicola

Defense date

2019

Abstract

Endometriosis has been traditionally viewed as a hormone-dependent disease where gonadic estrogens stimulate the proliferation of endometriosis implants, enhance chronic inflammation and prompt painful symptoms. Recently a more comprehensive understanding of this disease profiles endometriosis as an abnormal hormonal microenvironment characterized by increased estrogen responsiveness, progesterone resistance and aberrant estrogens synthesis and metabolism. This latter feature, other way defined intracrinology, plays a crucial role in sustaining the loop between estrogens, inflammation and pain. Further profiling intracrinology in endometriosis offers new basis for phenotypic characterization of the disease, drives the understanding of potential mechanisms of drug resistance and identifies new therapeutic targets.

UNIGE affiliation entities

Citation (ISO format)

PLUCHINO, Nicola. Is the Intracrinology of Endometriosis Relevant in Clinical Practice? Privat-docent Thesis, 2019. doi: 10.13097/archive-ouverte/unige:158175

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Technical informations

Creation

27/10/2020 15:44:00

First validation

27/10/2020 15:44:00

Update

13/10/2025 15:41:27

Status update

16/03/2023 02:25:42

Last indexation

04/01/2026 16:33:01
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