The impact of EPI-based distortion correction of dynamic susceptibility contrast MRI on cerebral blood volume estimation in patients with glioblastoma

Hovden, Ivar T; Geier, Oliver M; Digernes, Ingrid; Fuster-Garcia, Elies; Løvland, Grethe; Vik-Mo, Einar; Meling, Torstein; Emblem, Kyrre E

doi:10.1016/j.ejrad.2020.109278

Scientific article

English

The impact of EPI-based distortion correction of dynamic susceptibility contrast MRI on cerebral blood volume estimation in patients with glioblastoma

ContributorsHovden, Ivar T; Geier, Oliver M; Digernes, Ingrid; Fuster-Garcia, Elies; Løvland, Grethe; Vik-Mo, Einar; Meling, Torstein; Emblem, Kyrre E

Published inEuropean Journal of Radiology, vol. 132, 109278

Publication date2020

Abstract

Relative cerebral blood volume (rCBV) from dynamic susceptibility contrast (DSC)-MRI is a valuable biomarker in patients with glioblastoma for assessing treatment response and predicting overall survival. DSC-MRI based on echo planar images (EPI) may possess severe geometric distortions from magnetic field inhomogeneities up to the order of centimeters. The aim of this study is to assess how much two readily available EPI-based geometric distortion correction methods, FSL TOPUP and EPIC, affect rCBV values from DSC-MRI in patients with confirmed glioblastoma.

Keywords

Brain
Brain Neoplasms/diagnostic imaging
Cerebral Blood Volume
Contrast Media
Echo-Planar Imaging
Glioblastoma/diagnostic imaging
Humans
Magnetic Resonance Imaging

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

Research groups

Groupe Schaller Karl Lothard (neurochirurgie) (851)

Citation (ISO format)

HOVDEN, Ivar T et al. The impact of EPI-based distortion correction of dynamic susceptibility contrast MRI on cerebral blood volume estimation in patients with glioblastoma. In: European Journal of Radiology, 2020, vol. 132, p. 109278. doi: 10.1016/j.ejrad.2020.109278