Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study

Lamberink, Herm J; Otte, Willem M; Blümcke, Ingmar; Braun, Kees P J; European Reference Network EpiCARE study group; European Epilepsy Brain Bank writing group

doi:10.1016/S1474-4422(20)30220-9

Scientific article

English

Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study

ContributorsLamberink, Herm J; Otte, Willem M; Blümcke, Ingmar; Braun, Kees P J; European Reference Network EpiCARE study group; European Epilepsy Brain Bank writing group

CollaboratorsSchaller, Karl Lothard

Published inLancet neurology, vol. 19, no. 9, p. 748-757

Publication date2020

Abstract

Surgery is a widely accepted treatment option for drug-resistant focal epilepsy. A detailed analysis of longitudinal postoperative seizure outcomes and use of antiepileptic drugs for different brain lesions causing epilepsy is not available. We aimed to analyse the association between histopathology and seizure outcome and drug freedom up to 5 years after epilepsy surgery, to improve presurgical decision making and counselling.

Keywords

Adolescent
Adult
Aged
Anticonvulsants/therapeutic use
Child
Child
Preschool
Cohort Studies
Drug Resistant Epilepsy/drug therapy/pathology/surgery
Female
Humans
Infant
Longitudinal Studies
Male
Middle Aged
Retrospective Studies
Seizures/drug therapy/pathology/prevention & control
Treatment Outcome
Young Adult

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

Research groups

Groupe Schaller Karl Lothard (neurochirurgie) (851)

Funding

Citation (ISO format)

LAMBERINK, Herm J et al. Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study. In: Lancet neurology, 2020, vol. 19, n° 9, p. 748–757. doi: 10.1016/S1474-4422(20)30220-9

Article (Published version)

Identifiers

PID : unige:157965
DOI : 10.1016/S1474-4422(20)30220-9
PMID : 32822635

Journal ISSN1474-4422

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Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study

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