Scientific article
OA Policy
English

Systematic screening of viral and human genetic variation identifies antiretroviral resistance and immune escape link

Published ineLife, vol. 10
Publication date2021
Abstract

Considering the remaining threat of drug-resistantmutations (DRMs) to antiretroviral treatment (ART) efficacy, we investigated how the selective pressure of human leukocyte antigen (HLA)-restricted cytotoxic T lymphocytes drives certain DRMs' emergence and retention.

Keywords
  • HIV
  • HLA
  • epidemiology
  • global health
  • human
  • infectious disease
  • microbiology
  • mutations
Funding
  • Swiss National Science Foundation - FNS
Citation (ISO format)
NGUYEN, Huyen Tran et al. Systematic screening of viral and human genetic variation identifies antiretroviral resistance and immune escape link. In: eLife, 2021, vol. 10. doi: 10.7554/eLife.67388
Main files (1)
Article (Published version)
Identifiers
Journal ISSN2050-084X
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61downloads

Technical informations

Creation09/21/2021 12:57:00 PM
First validation09/21/2021 12:57:00 PM
Update time03/16/2023 2:20:41 AM
Status update03/16/2023 2:20:40 AM
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