Scientific article
English

Continuing versus tapering glucocorticoids after achievement of low disease activity or remission in rheumatoid arthritis (SEMIRA): a double-blind, multicentre, randomised controlled trial

Published inThe Lancet, vol. 396, no. 10246, p. 267-276
Publication date2020
Abstract

Patients with inflammatory diseases, such as rheumatoid arthritis, often receive glucocorticoids, but long-term use can produce adverse effects. Evidence from randomised controlled trials to guide tapering of oral glucocorticoids is scarce. We investigated a scheme for tapering oral glucocorticoids compared with continuing low-dose oral glucocorticoids in patients with rheumatoid arthritis.

Keywords
  • Administration
  • Intravenous
  • Administration
  • Oral
  • Adult
  • Aged
  • Antibodies
  • Monoclonal
  • Humanized/administration & dosage/therapeutic use
  • Arthritis
  • Rheumatoid/drug therapy/ethnology
  • Double-Blind Method
  • Drug Administration Schedule
  • Drug Therapy
  • Combination
  • Female
  • France/epidemiology
  • Germany/epidemiology
  • Glucocorticoids/administration & dosage/adverse effects/therapeutic use
  • Humans
  • Injections
  • Subcutaneous
  • Italy/epidemiology
  • Male
  • Middle Aged
  • Outcome Assessment
  • Health Care
  • Prednisone/administration & dosage/adverse effects/therapeutic use
  • Remission Induction/methods
  • Russia/epidemiology
  • Serbia/epidemiology
  • Tunisia/epidemiology
Citation (ISO format)
BURMESTER, Gerd R et al. Continuing versus tapering glucocorticoids after achievement of low disease activity or remission in rheumatoid arthritis (SEMIRA): a double-blind, multicentre, randomised controlled trial. In: The Lancet, 2020, vol. 396, n° 10246, p. 267–276. doi: 10.1016/S0140-6736(20)30636-X
Main files (1)
Article (Published version)
accessLevelRestricted
Secondary files (1)
Appendix
accessLevelRestricted
Identifiers
Journal ISSN0140-6736
309views
0downloads

Technical informations

Creation06/09/2021 15:43:00
First validation06/09/2021 15:43:00
Update24/01/2025 14:21:12
Status update24/01/2025 14:21:12
Last indexation24/01/2025 14:29:51
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack