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Scientific article
Open access
English

Maternal serum glycosylated fibronectin as a short-term predictor of preeclampsia: a prospective cohort study

Published inBMC Pregnancy and Childbirth, vol. 20, no. 1, 128
Publication date2020
Abstract

Preeclampsia is a major pregnancy complication that results in significant maternal and infant mortality, most of which occurs in low and middle-income countries. The accurate and timely diagnosis of preeclampsia is critical in management of affected pregnancies to reduce maternal and fetal/neonatal morbidity and mortality, yet difficulties remain in establishing the rigorous diagnosis of preeclampsia based on clinical parameters alone. Biomarkers that detect biochemical disease have been proposed as complements or alternatives to clinical criteria to improve diagnostic accuracy. This cohort study assessed the performance of several biomarkers, including glycosylated fibronectin (GlyFn), to rule-in or rule-out preeclampsia within 4 weeks in a cohort of women at increased risk for preeclampsia.

Keywords
  • Adult
  • Biomarkers / blood
  • Case-Control Studies
  • Cohort Studies
  • Female
  • Fibronectins / blood
  • Gestational Age
  • Glycation End Products, Advanced
  • Humans
  • Immunoassay
  • Placenta Growth Factor / blood
  • Pre-Eclampsia / blood
  • Pregnancy
  • Pregnancy Proteins / blood
  • Prospective Studies
  • ROC Curve
  • Risk Factors
  • Sensitivity and Specificity
  • Vascular Endothelial Growth Factor Receptor-1 / blood
Citation (ISO format)
HUHN, Evelyn A et al. Maternal serum glycosylated fibronectin as a short-term predictor of preeclampsia: a prospective cohort study. In: BMC Pregnancy and Childbirth, 2020, vol. 20, n° 1, p. 128. doi: 10.1186/s12884-020-2809-2
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Article (Published version)
Identifiers
ISSN of the journal1471-2393
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