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Title

Prevalence and Clinical Outcomes of Poor Immune Response Despite Virologically Suppressive Antiretroviral Therapy Among Children and Adolescents With Human Immunodeficiency Virus in Europe and Thailand: Cohort Study

CollaborationWith : Posfay Barbe, Klara
Published in Clinical infectious diseases. 2020, vol. 70, no. 3, p. 404-415
Abstract Background: In human immunodeficiency virus (HIV)–positive adults, low CD4 cell counts despite fully suppressed HIV-1 RNA on antiretroviral therapy (ART) have been associated with increased risk of morbidity and mortality. We assessed the prevalence and outcomes of poor immune response (PIR) in children receiving suppressive ART. Methods: Sixteen cohorts from the European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) contributed data. Children <18 years at ART initiation, with sustained viral suppression (VS) (≤400 copies/mL) for ≥1 year were included. The prevalence of PIR (defined as World Health Organization advanced/severe immunosuppression for age) at 1 year of VS was described. Factors associated with PIR were assessed using logistic regression. Rates of acquired immunodeficiency syndrome (AIDS) or death on suppressive ART were calculated by PIR status. Results: Of 2318 children included, median age was 6.4 years and 68% had advanced/severe immunosuppression at ART initiation. At 1 year of VS, 12% had PIR. In multivariable analysis, PIR was associated with older age and worse immunological stage at ART start, hepatitis B coinfection, and residing in Thailand (all P ≤ .03). Rates of AIDS/death (95% confidence interval) per 100 000 person-years were 1052 (547, 2022) among PIR versus 261 (166, 409) among immune responders; rate ratio of 4.04 (1.83, 8.92; P < .001). Conclusions: One in eight children in our cohort experienced PIR despite sustained VS. While the overall rate of AIDS/death was low, children with PIR had a 4-fold increase in risk of event as compared with immune responders.
Keywords AdolescentAdultAgedAnti-HIV Agents/therapeutic useAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountChildCohort StudiesEurope/epidemiologyFemaleHIVHIV Infections/drug therapy/epidemiologyHumansImmunityPregnancyPrevalenceThailand/epidemiologyViral Load
Identifiers
PMID: 30919882
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Article (Published version) (392 Kb) - public document Free access
Appendix (24 Kb) - public document Free access
Other version: https://academic.oup.com/cid/article/70/3/404/5421269
Structures
Research group Recherche en infectiologie pédiatrique et en pédiatrie générale (853)
Project
Swiss National Science Foundation: 148522
Citation
(ISO format)
EUROPEAN PREGNANCY AND PAEDIATRIC HIV COHORT COLLABORATION (EPPICC) STUDY GROUP IN EUROCOORD. Prevalence and Clinical Outcomes of Poor Immune Response Despite Virologically Suppressive Antiretroviral Therapy Among Children and Adolescents With Human Immunodeficiency Virus in Europe and Thailand: Cohort Study. In: Clinical Infectious Diseases, 2020, vol. 70, n° 3, p. 404-415. doi: 10.1093/cid/ciz253 https://archive-ouverte.unige.ch/unige:157721

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Deposited on : 2022-01-06

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