Scientific article
Open access

Vessels Sing Their ARIAs: The Role of Vascular Amyloid in the Age of Aducanumab

Published inStroke, vol. 53, no. 1, p. 298-302
Publication date2022-01
First online date2021-12-15

We review the implications of the recently approved aducanumab amyloid-β immunotherapy for treating Alzheimer disease with comorbid cerebral amyloid angiopathy. In clinical trials, amyloid-β immunotherapy has been associated with a high rate of amyloid-related imaging abnormalities, potentially driven by coexisting cerebral amyloid angiopathy. Therefore, immunotherapy's efficacy in patients may be modified by coexisting cerebrovascular pathology. We discuss the contributions of cerebral amyloid angiopathy on the development of amyloid-related imaging abnormalities and propose strategies to identify cerebral amyloid angiopathy in patients considered for immunotherapy.

  • Alzheimer disease
  • Amyloid
  • Cerebral amyloid angiopathy
  • Cerebrovascular disorders
  • Immunotherapy
  • Memory disorders
  • Mild cognitive impairment
Citation (ISO format)
SVEIKATA, Lukas, CHARIDIMOU, Andreas, VISWANATHAN, Anand. Vessels Sing Their ARIAs: The Role of Vascular Amyloid in the Age of Aducanumab. In: Stroke, 2022, vol. 53, n° 1, p. 298–302. doi: 10.1161/STROKEAHA.121.036873
Main files (1)
Article (Accepted version)
ISSN of the journal0039-2499

Technical informations

Creation12/27/2021 9:18:00 PM
First validation12/27/2021 9:18:00 PM
Update time03/16/2023 2:16:43 AM
Status update03/16/2023 2:16:43 AM
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