en
Scientific article
Open access
English

Sarilumab and adalimumab differential effects on bone remodelling and cardiovascular risk biomarkers, and predictions of treatment outcomes

Published inArthritis Research and Therapy, vol. 22, no. 1, 70
Publication date2020
Abstract

Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a key role in the pathogenesis of rheumatoid arthritis. Sarilumab is a human monoclonal antibody that binds membrane-bound and soluble IL-6 receptor-α to inhibit IL-6 signalling. The aim of this study was to compare the effects of sarilumab and adalimumab (a tumour necrosis factor alpha inhibitor) monotherapy on levels of circulating biomarkers associated with the acute-phase response, bone remodelling, atherothrombosis, anaemia of chronic disease and markers purported to reflect synovial lymphoid and myeloid cell infiltrates, as well as the potential of these biomarkers to differentially predict clinical and patient-reported outcomes with sarilumab vs. adalimumab.

Keywords
  • Adalimumab/therapeutic use
  • Adult
  • Aged
  • Antibodies
  • Monoclonal
  • Humanized/therapeutic use
  • Arthritis
  • Rheumatoid/blood/drug therapy/pathology
  • Biomarkers/blood
  • Bone Remodeling/drug effects
  • C-Reactive Protein/analysis
  • Cardiovascular Diseases/blood/prevention & control
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Matrix Metalloproteinase 3/blood
  • Middle Aged
  • Prospective Studies
  • Treatment Outcome
Citation (ISO format)
GABAY, Cem et al. Sarilumab and adalimumab differential effects on bone remodelling and cardiovascular risk biomarkers, and predictions of treatment outcomes. In: Arthritis Research and Therapy, 2020, vol. 22, n° 1, p. 70. doi: 10.1186/s13075-020-02163-6
Main files (1)
Article (Published version)
Identifiers
ISSN of the journal1478-6354
78views
30downloads

Technical informations

Creation09/06/2021 3:40:00 PM
First validation09/06/2021 3:40:00 PM
Update time03/16/2023 2:16:00 AM
Status update03/16/2023 2:15:59 AM
Last indexation02/12/2024 12:17:45 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack