en
Scientific article
Open access
English

Discrimination of COVID-19 from inflammation-induced cytokine storm syndromes using disease-related blood biomarkers

Published inArthritis and Rheumatology, vol. 73, no. 10, p. 1791-1799
Publication date2021
Abstract

Infection with the novel coronavirus SARS-CoV-2 triggers severe illness with high mortality in a subgroup of patients. Such a critical course of COVID-19 is thought to be associated with the development of cytokine storm, a condition seen in macrophage activation syndrome (MAS) and secondary hemophagocytic lymphohistiocytosis (HLH). However, specific data demonstrating a clear association of cytokine storm with severe COVID-19 are still lacking. The aim of this study was to directly address whether immune activation in COVID-19 does indeed mimic the conditions found in these classic cytokine storm syndromes.

Keywords
  • Adolescent
  • Adult
  • Aged
  • Aged
  • 80 and over
  • Biomarkers / blood
  • COVID-19 / blood
  • COVID-19 / complications
  • COVID-19 / diagnosis*
  • Cytokine Release Syndrome / blood
  • Cytokine Release Syndrome / etiology*
  • Diagnosis
  • Differential
  • Female
  • Humans
  • Interleukin-18 / blood*
  • Interleukin-8 / blood*
  • Lymphohistiocytosis
  • Hemophagocytic / blood
  • Lymphohistiocytosis
  • Hemophagocytic / complications
  • Lymphohistiocytosis
  • Hemophagocytic / diagnosis*
  • Macrophage Activation Syndrome / blood
  • Macrophage Activation Syndrome / complications
  • Macrophage Activation Syndrome / diagnosis*
  • Male
  • Middle Aged
  • Young Adult
Citation (ISO format)
KESSEL, Christoph et al. Discrimination of COVID-19 from inflammation-induced cytokine storm syndromes using disease-related blood biomarkers. In: Arthritis and Rheumatology, 2021, vol. 73, n° 10, p. 1791–1799. doi: 10.1002/art.41763
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Article (Published version)
Identifiers
ISSN of the journal2326-5191
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185downloads

Technical informations

Creation09/06/2021 3:36:00 PM
First validation09/06/2021 3:36:00 PM
Update time03/16/2023 2:15:56 AM
Status update03/16/2023 2:15:55 AM
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