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Scientific article
Open access
English

Altered structural connectivity networks in dementia with lewy bodies

Published inBrain imaging and behavior, vol. 15, no. 5, p. 2445-2453
Publication date2021-10
First online date2021-01-29
Abstract

The impairment of large-scale brain networks has been observed in dementia with Lewy bodies (DLB) using functional connectivity, but the potential for an analogous effect on structural covariance patterns has not been determined. Twenty-four probable DLB subjects (mean age 74.3 ± 6.7 years, 16.7% female) and 23 similarly aged Controls were included. All participants underwent 3T MRI imaging with high-resolution T1-weighted magnetization-prepared rapid gradient echo (MPRAGE) sequence. Graph theoretical analyses were performed using variation in regional cortical thickness to construct a structural association matrix with pairwise Pearson correlations. Global and nodal graph parameters were computed to assess between-group differences and community structure was studied in order to quantify large-scale brain networks in both groups. In comparison to Controls, DLB subjects had decreased global efficiency, clustering, modularity and small-worldness of structural networks (all p < 0.05). Nodal measures showed that DLB subjects also had decreased clustering in bilateral temporal regions and decreased closeness centrality in extensive areas including right middle frontal, left cingulate and bilateral occipital lobe (all false-discovery rate (FDR)-corrected q < 0.05). Whereas four distinct modules could be clearly identified in Controls, DLB showed extensively disorganized modules, including default-mode network and dorsal attentional network. Our results suggest a marked impairment in large-scale brain structural networks in DLB, mirroring functional connectivity networks disruption.

eng
Keywords
  • Brain network
  • Cortical thickness
  • Dementia
  • Graph theory
  • MRI
Funding
  • Wellcome Trust - Restoring brain function: from cortical microcircuits to complex behaviours in neurodegenerative disease. [103838]
  • Medical Research Council of Cognition and Brain Sciences Unit, Cambridge - [MC-A060-5PQ30]
  • National Institute for Health Research (NIHR) - [RG64473]
Citation (ISO format)
NICASTRO, Nicolas et al. Altered structural connectivity networks in dementia with lewy bodies. In: Brain imaging and behavior, 2021, vol. 15, n° 5, p. 2445–2453. doi: 10.1007/s11682-020-00444-x
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Article (Published version)
Identifiers
ISSN of the journal1931-7557
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Creation10/08/2021 6:47:00 PM
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