Background: Bipolar disorder is a severe and chronic mental illness characterized by recurrent major depressive episodes and mania or hypomania during the course of the illness. In addition to the burden of the disease and its consequences, people living with severe mental illness have a propensity to selfstigma that is being aware of and internalizing public stigma. This review examines self-stigma in bipolar disorder. Methods: An electronic search was carried out during the last week of August 2020. Three academic databases – PubMed, Embase, and PsycInfo – were systematically searched, based on the PRISMA guidelines. Results: Fifty-six articles concern the question of self-stigma in bipolar disorder. The following key themes emerge from this review: 1/ Comparison of self-stigma in bipolar disorder and other mental illnesses, 2/ Sociocultural context and self-stigma, 3/ Correlates and predictors of self-stigma, 4/ Consequences of self-stigma, 5/ Treatments and self-stigma, 6/ Management of self-stigma, and 7/ Selfstigma and recovery in bipolar disorder. Conclusion: Like many other people with severe mental illness, people living with bipolar disorder are highly self-stigmatized, and this self-stigma has critical impacts on their lives. Some interventions intended to reduce self-stigmatization have been developed but evidence of their effectiveness is still sparse. Clinicians need to be more aware of and attentive to self-stigma, its assessment and its empowerment in their daily clinical practice. Future work is required to establish valid strategies to fight self-stigma.