en
Scientific article
Open access
English

A life course approach to explore the biological embedding of socioeconomic position and social mobility through circulating inflammatory markers

Published inScientific Reports, vol. 6, 25170
Publication date2016
Abstract

Lower socioeconomic position (SEP) has consistently been associated with poorer health. To explore potential biological embedding and the consequences of SEP experiences from early life to adulthood, we investigate how SEP indicators at different points across the life course may be related to a combination of 28 inflammation markers. Using blood-derived inflammation profiles measured by a multiplex array in 268 participants from the Italian component of the European Prospective Investigation into Cancer and Nutrition cohort, we evaluate the association between early life, young adulthood and later adulthood SEP with each inflammatory markers separately, or by combining them into an inflammatory score. We identified an increased inflammatory burden in participants whose father had a manual occupation, through increased plasma levels of CSF3 (G-CSF; β = 0.29; P = 0.002), and an increased inflammatory score (β = 1.96; P = 0.029). Social mobility was subsequently modelled by the interaction between father's occupation and the highest household occupation, revealing a significant difference between "stable Non-manual" profiles over the life course versus "Manual to Non-manual" profiles (β = 2.38, P = 0.023). Low SEP in childhood is associated with modest increase in adult inflammatory burden; however, the analysis of social mobility suggests a stronger effect of an upward social mobility over the life course.

Keywords
  • Adult
  • Biomarkers/blood
  • Europe
  • Female
  • Granulocyte Colony-Stimulating Factor/blood
  • Humans
  • Inflammation/blood
  • Male
  • Middle Aged
  • Prospective Studies
  • Risk Factors
  • Social Mobility
Affiliation Not a UNIGE publication
Citation (ISO format)
CASTAGNÉ, Raphaële et al. A life course approach to explore the biological embedding of socioeconomic position and social mobility through circulating inflammatory markers. In: Scientific Reports, 2016, vol. 6, p. 25170. doi: 10.1038/srep25170
Main files (1)
Article (Published version)
Secondary files (1)
Identifiers
ISSN of the journal2045-2322
98views
71downloads

Technical informations

Creation05/31/2021 11:42:00 AM
First validation05/31/2021 11:42:00 AM
Update time03/16/2023 2:06:46 AM
Status update03/16/2023 2:06:44 AM
Last indexation02/12/2024 12:16:45 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack