Association of lifecourse socioeconomic status with chronic inflammation and type 2 diabetes risk: the Whitehall II prospective cohort study

Stringhini, Silvia; Batty, G David; Bovet, Pascal; Shipley, Martin J; Marmot, Michael G; Kumari, Meena; Tabak, Adam G; Kivimäki, Mika

doi:10.1371/journal.pmed.1001479

Article scientifique

Accès libre

Anglais

Association of lifecourse socioeconomic status with chronic inflammation and type 2 diabetes risk: the Whitehall II prospective cohort study

Contributeurs/tricesStringhini, Silvia; Batty, G David; Bovet, Pascal; Shipley, Martin J; Marmot, Michael G; Kumari, Meena; Tabak, Adam G; Kivimäki, Mika

Publié dansPLOS Medicine, vol. 10, no. 7, e1001479

Date de publication2013

Résumé

Socioeconomic adversity in early life has been hypothesized to "program" a vulnerable phenotype with exaggerated inflammatory responses, so increasing the risk of developing type 2 diabetes in adulthood. The aim of this study is to test this hypothesis by assessing the extent to which the association between lifecourse socioeconomic status and type 2 diabetes incidence is explained by chronic inflammation.

Mots-clés

Adult
Biomarkers/blood
C-Reactive Protein/metabolism
Cohort Studies
Diabetes Mellitus, Type 2/epidemiology/etiology
Female
Humans
Incidence
Inflammation/complications/epidemiology
Interleukin-6/blood
Male
Middle Aged
Prospective Studies
Risk Factors
Social Class
United Kingdom/epidemiology

Structure d'affiliation Pas une publication de l'UNIGE

Citation (format ISO)

STRINGHINI, Silvia et al. Association of lifecourse socioeconomic status with chronic inflammation and type 2 diabetes risk: the Whitehall II prospective cohort study. In: PLOS Medicine, 2013, vol. 10, n° 7, p. e1001479. doi: 10.1371/journal.pmed.1001479