Host genomics of the HIV-1 reservoir size and its decay rate during suppressive antiretroviral treatment

Thorball, Christian W; Borghesi, Alessandro; Bachmann, Nadine; Von Siebenthal, Chantal; Vongrad, Valentina; Turk, Teja; Neumann, Kathrin; Beerenwinkel, Niko; Bogojeska, Jasmina; Roth, Volker; Kok, Yik Lim; Parbhoo, Sonali; Wieser, Mario; Böni, Jürg; Perreau, Matthieu; Klimkait, Thomas; Yerly Ferrillo, Sabine; Battegay, Manuel; Rauch, Andri; Schmid, Patrick; Bernasconi, Enos; Cavassini, Matthias; Kouyos, Roger D; Günthard, Huldrych F; Metzner, Karin J; Fellay, Jacques

doi:10.1097/QAI.0000000000002473

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Title		Host genomics of the HIV-1 reservoir size and its decay rate during suppressive antiretroviral treatment
Authors		Thorball, Christian W Borghesi, Alessandro Bachmann, Nadine Von Siebenthal, Chantal Vongrad, Valentina Turk, Teja Neumann, Kathrin Beerenwinkel, Niko Bogojeska, Jasmina Roth, Volker Kok, Yik Lim Parbhoo, Sonali Wieser, Mario Böni, Jürg Perreau, Matthieu Klimkait, Thomas Yerly Ferrillo, Sabine Battegay, Manuel Rauch, Andri Schmid, Patrick Bernasconi, Enos Cavassini, Matthias Kouyos, Roger D Günthard, Huldrych F Metzner, Karin J Fellay, Jacques show all authors [1 - 26]
Collaboration		Swiss HIV Cohort Study
Published in		Journal of Acquired Immune Deficiency Syndromes. 2020, vol. 85, no. 4, p. 517-524
Abstract		The primary hurdle for the eradication of HIV-1 is the establishment of a latent viral reservoir early after primary infection. Here, we investigated the potential influence of human genetic variation on the HIV-1 reservoir size and its decay rate during suppressive antiretroviral treatment.
Keywords		Anti-HIV Agents/therapeutic use — Genetic Predisposition to Disease — Genetic Variation — Genome — Human — Genome-Wide Association Study — Genomics/methods — Genotype — HIV Infections/drug therapy/genetics — HIV-1 — Humans — Time Factors
Identifiers		DOI: 10.1097/QAI.0000000000002473 PMID: 33136754
Full text		Article (Published version) (298 Kb) - Limited access to UNIGE Supplemental data (2.6 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Research group		Groupe Laurent Kaiser (virologie clinique) (668)
Citation (ISO format)		THORBALL, Christian W et al. Host genomics of the HIV-1 reservoir size and its decay rate during suppressive antiretroviral treatment. In: Journal of Acquired Immune Deficiency Syndromes, 2020, vol. 85, n° 4, p. 517-524. doi: 10.1097/QAI.0000000000002473 https://archive-ouverte.unige.ch/unige:157059