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Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART.

Wan, Chenjie
Bachmann, Nadine
Mitov, Venelin
Blanquart, François
Céspedes, Susana Posada
Turk, Teja
Neumann, Kathrin
Beerenwinkel, Niko
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CollaborationWith : Kaiser, Laurent
Published in Nature communications. 2020, vol. 11, no. 1, 5542
Abstract The HIV-1 reservoir is the major hurdle to curing HIV-1. However, the impact of the viral genome on the HIV-1 reservoir, i.e. its heritability, remains unknown. We investigate the heritability of the HIV-1 reservoir size and its long-term decay by analyzing the distribution of those traits on viral phylogenies from both partial-pol and viral near full-length genome sequences. We use a unique nationwide cohort of 610 well-characterized HIV-1 subtype-B infected individuals on suppressive ART for a median of 5.4 years. We find that a moderate but significant fraction of the HIV-1 reservoir size 1.5 years after the initiation of ART is explained by genetic factors. At the same time, we find more tentative evidence for the heritability of the long-term HIV-1 reservoir decay. Our findings indicate that viral genetic factors contribute to the HIV-1 reservoir size and hence the infecting HIV-1 strain may affect individual patients' hurdle towards a cure.
Keywords AdultAnti-Retroviral Agents/pharmacologyCD4-Positive T-Lymphocytes/virologyCohort StudiesDNAViral/geneticsFemaleGenomeViralHIV Infections/virologyHIV-1/drug effects/geneticsHumansMaleTime FactorsViral Load
PMID: 33139735
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Research groups Groupe Laurent Kaiser (virologie clinique) (668)
VIH/SIDA (930)
Swiss National Science Foundation: 324730B_179571, 310030_141067/1
Swiss National Science Foundation: PZ00P3_142411
Swiss National Science Foundation: PZ00P3-142411 and BSSGI0_155851 to R.D.K
(ISO format)
WAN, Chenjie et al. Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART. In: Nature Communications, 2020, vol. 11, n° 1, p. 5542. doi: 10.1038/s41467-020-19198-7 https://archive-ouverte.unige.ch/unige:157057

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Deposited on : 2021-12-13

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