en
Scientific article
Review
English

Biological embedding of early-life exposures and disease risk in humans: a role for DNA methylation

Published inEuropean Journal of Clinical Investigation, vol. 45, no. 3, p. 303-332
Publication date2015
Abstract

Following wider acceptance of 'the thrifty phenotype' hypothesis and the convincing evidence that early-life exposures can influence adult health even decades after the exposure, much interest has been placed on the mechanisms through which early-life exposures become biologically embedded.

Keywords
  • Adolescent
  • Adult
  • Aged
  • Aged
  • 80 and over
  • Body Mass Index
  • Child
  • Child Nutritional Physiological Phenomena/physiology
  • Child
  • Preschool
  • DNA Methylation/physiology
  • Disease Susceptibility/etiology
  • Environmental Exposure/adverse effects
  • Epigenesis
  • Genetic/physiology
  • Female
  • Humans
  • Infant
  • Life Change Events
  • Male
  • Middle Aged
  • Pediatric Obesity/complications
  • Risk Factors
  • Socioeconomic Factors
  • Young Adult
Affiliation Not a UNIGE publication
Citation (ISO format)
DEMETRIOU, Christiana A et al. Biological embedding of early-life exposures and disease risk in humans: a role for DNA methylation. In: European Journal of Clinical Investigation, 2015, vol. 45, n° 3, p. 303–332. doi: 10.1111/eci.12406
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0014-2972
106views
0downloads

Technical informations

Creation05/25/2021 3:29:00 PM
First validation05/25/2021 3:29:00 PM
Update time03/16/2023 2:02:23 AM
Status update03/16/2023 2:02:22 AM
Last indexation01/17/2024 3:28:44 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack