As exchanges of instrumental support between kin and non-kin remain essential to buffer the impact of critical life events, we consider the characteristics of personal configurations that may enhance or hinder them. Personal configurations vary in terms of their composition and two aspects of their structure: density and centrality. These dimensions are investigated to uncover whether they influence the type of instrumental support being exchanged (financial, material, and care) and the likelihood of their being reciprocal. Drawing on a representative sample of individuals living in Switzerland, results show that overall instrumental support is present in all personal configurations irrespective of their composition, but financial support is more prevalent in configurations based on parent–adult child relationships. Furthermore, configuration structures characterized by density of emotional support are positively associated with giving care support and with reciprocity, while those characterized by density of conflict are associated with giving less instrumental support overall.