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Scientific article
English

Ultimate Fate of Rod Outer Segments in the Retinal Pigment Epithelium

Published inPigment cell research, vol. 12, no. 5, p. 311-315
Publication date1999-10
Abstract

To investigate the degradation pathway of rod outer segments (ROS) in vivo, we injected gold-labeled ROS into the subretinal space of rabbits using a pars plana approach. Histology and electron microscopy performed on the specimens 72 hr after ROS injection revealed that the retina over the injection site was reattached, the retinal pigment epithelial (RPE) cells were intact, and gold granules were localized inside melanin granules and melanosomes. These results indicate that, in RPE, in vivo degradation of ROS is associated with melanosomes.

eng
Keywords
  • Animals Rabbits
  • Lipofuscin
  • Lysosomes
  • Melanins Microscopy
  • Electron
  • Pigment Epithelium of Eye
  • Rod Cell Outer Segment
  • Gold
Affiliation Not a UNIGE publication
Citation (ISO format)
THUMANN, Gabriele et al. Ultimate Fate of Rod Outer Segments in the Retinal Pigment Epithelium. In: Pigment cell research, 1999, vol. 12, n° 5, p. 311–315. doi: 10.1111/j.1600-0749.1999.tb00764.x
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Article (Published version)
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ISSN of the journal0893-5785
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