en
Scientific article
Open access
English

Validation of questionnaire-reported chest wall abnormalities with a telephone interview in Swiss childhood cancer survivors

ContributorsKasteler, Rahelorcid; Lichtensteiger, Christa; Schindera, Christina; Ansari Djaberi, Marc Georges; Kuehni, Claudia Eorcid; Swiss Pediatric Oncology Group (SPOG) Scientific Committee
Published inBMC cancer, vol. 21, no. 1, 787
Publication date2021-07-08
First online date2021-07-08
Abstract

Background: Chest wall abnormalities are a poorly studied complication after treatment for childhood cancer. Chest wall abnormalities are not well-described in the literature, and little is known on the impact on daily life of survivors.

Methods: We investigated prevalence and risk factors of chest wall abnormalities in childhood cancer survivors in a nationwide, population-based cohort study (Swiss Childhood Cancer Survivor Study) with a questionnaire survey. We then interviewed a nested sample of survivors to validate types of chest wall abnormalities and understand their impact on the daily life of survivors.

Results: Forty-eight of 2382 (95%CI 2-3%) survivors reported a chest wall abnormality. Risk factors were older age at cancer diagnosis (16-20 years; OR 2.5, 95%CI 1.0-6.1), lymphoma (OR 3.8, 95%CI 1.2-11.4), and central nervous system tumors (OR 9.5, 95%CI 3.0-30.1) as underlying disease, and treatment with thoracic radiotherapy (OR 2.0, 95%CI 1.0-4.2), surgery to the chest (OR 4.5, 95%CI 1.8-11.5), or chemotherapy (OR 2.9, 95%CI 1.0-8.1). The nature of the chest wall abnormalities varied and included thoracic wall deformities (30%), deformations of the spine (5%) or both (55%), and scars (10%). Chest wall abnormalities affected daily life in two thirds (13/20) of those who reported these problems and necessitated medical attention for 15 (75%) survivors.

Conclusion: It is important that, during follow-up care, physicians pay attention to chest wall abnormalities, which are rare late effects of cancer treatment, but can considerably affect the well-being of cancer survivors.

eng
Keywords
  • Cancer treatment
  • Chest wall deformity
  • Late effects
  • Swiss Childhood Cancer Survivor Study
Funding
  • Swiss Cancer League - [KFS-4157-02-2017]
  • Swiss Cancer League - [KLS-3886-02-2016]
Citation (ISO format)
KASTELER, Rahel et al. Validation of questionnaire-reported chest wall abnormalities with a telephone interview in Swiss childhood cancer survivors. In: BMC cancer, 2021, vol. 21, n° 1, p. 787. doi: 10.1186/s12885-021-08425-z
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Article (Published version)
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Identifiers
ISSN of the journal1471-2407
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Creation10/14/2021 10:11:00 AM
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