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Scientific article
Review
Open access
English

Structural Insights into TOR Signaling

Published inGenes, vol. 11, no. 8, 885
Publication date2020-08-04
First online date2020-08-04
Abstract

The Target of Rapamycin (TOR) is a highly conserved serine/threonine protein kinase that performs essential roles in the control of cellular growth and metabolism. TOR acts in two distinct multiprotein complexes, TORC1 and TORC2 (mTORC1 and mTORC2 in humans), which maintain different aspects of cellular homeostasis and orchestrate the cellular responses to diverse environmental challenges. Interest in understanding TOR signaling is further motivated by observations that link aberrant TOR signaling to a variety of diseases, ranging from epilepsy to cancer. In the last few years, driven in large part by recent advances in cryo-electron microscopy, there has been an explosion of available structures of (m)TORC1 and its regulators, as well as several (m)TORC2 structures, derived from both yeast and mammals. In this review, we highlight and summarize the main findings from these reports and discuss both the fascinating and unexpected molecular biology revealed and how this knowledge will potentially contribute to new therapeutic strategies to manipulate signaling through these clinically relevant pathways.

Keywords
  • Cell growth homeostasis
  • Structural biology
  • Target of rapamycin
Research group
Funding
  • European Research Council - [TENDO]
Citation (ISO format)
TAFUR PETROZZI, Lucas, KEFAUVER, Jennifer Marie, LOEWITH, Robbie Joséph. Structural Insights into TOR Signaling. In: Genes, 2020, vol. 11, n° 8, p. 885. doi: 10.3390/genes11080885
Main files (1)
Article (Published version)
Identifiers
ISSN of the journal2073-4425
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38downloads

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