en
Scientific article
Review
Open access
English

Bioengineered Islet Cell Transplantation

Published inCurrent transplantation reports, vol. 8, no. 2, p. 57-66
Publication date2021-06
First online date2021-03-13
Abstract

Purpose of Review : β cell replacement via whole pancreas or islet transplantation has greatly evolved for the cure of type 1 diabetes. Both these strategies are however still affected by several limitations. Pancreas bioengineering holds the potential to overcome these hurdles aiming to repair and regenerate β cell compartment. In this review, we detail the state-of-the-art and recent progress in the bioengineering field applied to diabetes research. Recent Findings : The primary target of pancreatic bioengineering is to manufacture a construct supporting insulin activity in vivo. Scaffold-base technique, 3D bioprinting, macro-devices, insulin-secreting organoids, and pancreas-on-chip represent the most promising technologies for pancreatic bioengineering. Summary: There are several factors affecting the clinical application of these technologies, and studies reported so far are encouraging but need to be optimized. Nevertheless pancreas bioengineering is evolving very quickly and its combination with stem cell research developments can only accelerate this trend.

eng
Keywords
  • Diabetes
  • Beta cells
  • Islets of Langerhans
  • Islet transplantation
  • Biomaterials
  • Tissue engineering
  • Pancreas-on-chip
  • Regenerative medicine
  • 3D bioprinting
Citation (ISO format)
BELLOFATTO, Kevin et al. Bioengineered Islet Cell Transplantation. In: Current transplantation reports, 2021, vol. 8, n° 2, p. 57–66. doi: 10.1007/s40472-021-00318-1
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Article (Published version)
Identifiers
ISSN of the journal2196-3029
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60downloads

Technical informations

Creation12/06/2021 10:05:00 AM
First validation12/06/2021 10:05:00 AM
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