Significance of PR3-ANCA positivity in eosinophilic granulomatosis with polyangiitis (Churg-Strauss)

Papo, Matthias; Sinico, Renato A; Teixeira, Vítor; Venhoff, Nils; Urban, Maria-Letizia; Iudici, Michele; Mahrhold, Juliane; Locatelli, Francesco; Cassone, Giulia; Schiavon, Franco; Seeliger, Benjamin; Neumann, Thomas; Kroegel, Claus; Groh, Matthieu; Marvisi, Chiara; Samson, Maxime; Barba, Thomas; Jayne, David; Troilo, Arianna; Thiel, Jens; Hellmich, Bernhard; Monti, Sara; Montecucco, Carlomaurizio; Salvarani, Carlo; Kahn, Jean-Emmanuel; Bonnotte, Bernard; Durel, Cécile-Audrey; Puéchal, Xavier; Mouthon, Luc; Guillevin, Loïc; Emmi, Giacomo; Vaglio, Augusto; Terrier, Benjamin; French Vasculitis Study Group and the EGPA European Study Group

doi:10.1093/rheumatology/keaa805

Scientific article

English

Significance of PR3-ANCA positivity in eosinophilic granulomatosis with polyangiitis (Churg-Strauss)

ContributorsPapo, Matthias; Sinico, Renato A; Teixeira, Vítor; Venhoff, Nils; Urban, Maria-Letizia; Iudici, Michele

; Mahrhold, Juliane; Locatelli, Francesco; Cassone, Giulia; Schiavon, Franco; Seeliger, Benjamin; Neumann, Thomas; Kroegel, Claus; Groh, Matthieu; Marvisi, Chiara; Samson, Maxime; Barba, Thomas; Jayne, David; Troilo, Arianna; Thiel, Jens; Hellmich, Bernhard; Monti, Sara; Montecucco, Carlomaurizio; Salvarani, Carlo; Kahn, Jean-Emmanuel; Bonnotte, Bernard; Durel, Cécile-Audrey; Puéchal, Xavier; Mouthon, Luc; Guillevin, Loïc; Emmi, Giacomo; Vaglio, Augusto; Terrier, Benjamin; French Vasculitis Study Group and the EGPA European Study Group

Published inRheumatology, vol. 60, no. 9, p. 4355-4360

Publication date2021

Abstract

Only a third of patients with eosinophilic granulomatosis with polyangiitis (EGPA) are ANCA-positive, mainly directed against MPO. ANCA directed against PR3 are rarely found in EGPA. We aimed to examine the significance of PR3-ANCA in EGPA.

Keywords

ANCA
Churg-Strauss
Vasculitis

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Inflammation articulaire (44)

Citation (ISO format)

PAPO, Matthias et al. Significance of PR3-ANCA positivity in eosinophilic granulomatosis with polyangiitis (Churg-Strauss). In: Rheumatology, 2021, vol. 60, n° 9, p. 4355–4360. doi: 10.1093/rheumatology/keaa805

Article (Published version)

Identifiers

PID : unige:156894
DOI : 10.1093/rheumatology/keaa805
PMID : 33347592

Journal ISSN1462-0324

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Creation31/08/2021 09:00:00

First validation31/08/2021 09:00:00

Update08/09/2025 07:36:59

Status update08/09/2025 07:36:59

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Significance of PR3-ANCA positivity in eosinophilic granulomatosis with polyangiitis (Churg-Strauss)

Only a third of patients with eosinophilic granulomatosis with polyangiitis (EGPA) are ANCA-positive, mainly directed against MPO. ANCA directed against PR3 are rarely found in EGPA. We aimed to examine the significance of PR3-ANCA in EGPA.

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