UNIGE document Scientific Article
previous document  unige:156718  next document
add to browser collection
Title

Complete Excision of Primary Breast Tumor Improves Survival of Patients With Metastatic Breast Cancer at Diagnosis

Authors
Sappino, André Pascal
Published in Journal of Clinical Oncology. 2006, vol. 24, no. 18, p. 2743-2749
Abstract

Purpose: Surgery of the primary tumor usually is not advised for patients with metastatic breast cancer at diagnosis because the disease is considered incurable. In this population-based study, we evaluate the impact of local surgery on survival of patients with metastatic breast cancer at diagnosis.

Methods: We included all 300 metastatic breast cancer patients recorded at the Geneva Cancer Registry between 1977 and 1996. We compared mortality risks from breast cancer between patients who had surgery of the primary breast tumor to those who had not and adjusted these risks for other prognostic factors.

Results: Women who had complete excision of the primary breast tumor with negative surgical margins had a 40% reduced risk of death as a result of breast cancer (multiadjusted hazard ratio [HR], 0.6; 95% CI, 0.4 to 1.0) compared with women who did not have surgery (P = .049). This mortality reduction was not significantly different among patients with different sites of metastasis, but in the stratified analysis the effect was particularly evident for women with bone metastasis only (HR, 0.2; 95% CI, 0.1 to 0.4; P = .001). Survival of women who had surgery with positive surgical margins was not different from that of women who did not have surgery.

Conclusion: Complete surgical excision of the primary tumor improves survival of patients with metastatic breast cancer at diagnosis, particularly among women with only bone metastases.

Identifiers
PMID: 16702580
Full text
Article (Published version) (362 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://ascopubs.org/doi/10.1200/JCO.2005.04.2226
Structures
Research group Epidémiologie des tumeurs (1017)
Project
Swiss National Science Foundation: 323-3069350
Citation
(ISO format)
RAPITI AYLWARD, Elisabetta et al. Complete Excision of Primary Breast Tumor Improves Survival of Patients With Metastatic Breast Cancer at Diagnosis. In: Journal of Clinical Oncology, 2006, vol. 24, n° 18, p. 2743-2749. doi: 10.1200/JCO.2005.04.2226 https://archive-ouverte.unige.ch/unige:156718

16 hits

1 download

Update

Deposited on : 2021-11-25

Export document
Format :
Citation style :