en
Scientific article
English

ABO incompatibile graft management in pediatric transplantation

Published inBone marrow transplantation, vol. 56, no. 1, p. 84-90
Errata
  • The original version of this Article contained an error in the spelling of the authors Andrea Jarisch and Jochen Buechner, which were incorrectly given as Andrea Järisch and Jochen Büchner. This has now been corrected in both the PDF and HTML versions of the Article.
  • DOI : 10.1038/s41409-020-01012-z
  • PMID : 32753704
Publication date2021-01
First online date2020-06-27
Abstract

Up to 40% of donor-recipient pairs in SCT have some degree of ABO incompatibility, which may cause severe complications. The aim of this study was to describe available options and survey current practices by means of a questionnaire circulated within the EBMT Pediatric Diseases Working Party investigators. Major ABO incompatibility (donor's RBCs have antigens missing on the recipient's cell surface, towards which the recipient has circulating isohemagglutinins) requires most frequently an intervention in case of bone marrow grafts, as immediate or delayed hemolysis, delayed erythropoiesis and pure red cell aplasia may occur. RBC depletion from the graft (82%), recipient plasma-exchange (14%) were the most common practices, according to the survey. Graft manipulation is rarely needed in mobilized peripheral blood grafts. In case of minor incompatible grafts (donor has isohemagglutinins directed against recipient RBC antigens), isohemagglutinin depletion from the graft by plasma reduction/centrifugation may be considered, but acute tolerability of minor incompatible grafts is rarely an issue. According to the survey, minor ABO incompatibility was either managed by means of plasma removal from the graft, especially when isohemagglutinin titer was above a certain threshold, or led to no intervention at all (41%). Advantages and disadvantages of each method are discussed.

eng
Keywords
  • ABO Blood-Group System
  • Blood Group Incompatibility
  • Bone Marrow Transplantation
  • Child
  • Erythrocytes
  • Hemolysis
  • Humans
Citation (ISO format)
BALDUZZI, Adriana et al. ABO incompatibile graft management in pediatric transplantation. In: Bone marrow transplantation, 2021, vol. 56, n° 1, p. 84–90. doi: 10.1038/s41409-020-0981-7
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Article (Published version)
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Identifiers
ISSN of the journal0268-3369
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Creation10/14/2021 12:11:00 PM
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