Effects of cold or warm ischemia and ex-vivo lung perfusion on the release of damage associated molecular patterns and inflammatory cytokines in experimental lung transplantation

Hasenauer, Arpad; Bedat, Benoît; Parapanov, Roumen; Lugrin, Jérôme; Debonneville, Anne; Abdelnour-Berchtold, Etienne; Gonzalez, Michel; Perentes, Jean Y; Piquilloud, Lise; Szabo, Csaba; Krueger, Thorsten; Liaudet, Lucas

doi:10.1016/j.healun.2021.05.015

Scientific article

English

Effects of cold or warm ischemia and ex-vivo lung perfusion on the release of damage associated molecular patterns and inflammatory cytokines in experimental lung transplantation

ContributorsHasenauer, Arpad; Bedat, Benoît; Parapanov, Roumen; Lugrin, Jérôme; Debonneville, Anne; Abdelnour-Berchtold, Etienne; Gonzalez, Michel; Perentes, Jean Y; Piquilloud, Lise; Szabo, Csaba; Krueger, Thorsten; Liaudet, Lucas

Published inThe Journal of heart and lung transplantation, vol. 40, no. 9, p. 905-916

Publication date2021

Abstract

Lung transplantation (LTx) is associated with sterile inflammation, possibly related to the release of damage associated molecular patterns (DAMPs) by injured allograft cells. We have measured cellular damage and the release of DAMPs and cytokines in an experimental model of LTx after cold or warm ischemia and examined the effect of pretreatment with ex-vivo lung perfusion (EVLP).

Keywords

Animal model
Ex-vivo lung perfusion
Inflammation
Innate immunity
Lung Transplantation

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de chirurgie

Research groups

Cancer du poumon et mésothéliome pleural malin (944)

Funding

Citation (ISO format)

HASENAUER, Arpad et al. Effects of cold or warm ischemia and ex-vivo lung perfusion on the release of damage associated molecular patterns and inflammatory cytokines in experimental lung transplantation. In: The Journal of heart and lung transplantation, 2021, vol. 40, n° 9, p. 905–916. doi: 10.1016/j.healun.2021.05.015