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Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis

Hinterdobler, Julia
Schott, Simin
Jin, Hong
Meesmann, Almut
Steinsiek, Anna-Lena
Zimmermann, Anna-Sophia
Wobst, Jana
Müller, Philipp
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Published in European Heart Journal. 2021, vol. 42, no. 39, p. 4077-4088
Abstract Mental stress substantially contributes to the initiation and progression of human disease, including cardiovascular conditions. We aim to investigate the underlying mechanisms of these contributions since they remain largely unclear.

Here, we show in humans and mice that leucocytes deplete rapidly from the blood after a single episode of acute mental stress. Using cell-tracking experiments in animal models of acute mental stress, we found that stress exposure leads to prompt uptake of inflammatory leucocytes from the blood to distinct tissues including heart, lung, skin, and, if present, atherosclerotic plaques. Mechanistically, we found that acute stress enhances leucocyte influx into mouse atherosclerotic plaques by modulating endothelial cells. Specifically, acute stress increases adhesion molecule expression and chemokine release through locally derived norepinephrine. Either chemical or surgical disruption of norepinephrine signalling diminished stress-induced leucocyte migration into mouse atherosclerotic plaques.

Our data show that acute mental stress rapidly amplifies inflammatory leucocyte expansion inside mouse atherosclerotic lesions and promotes plaque vulnerability.

Keywords Acute mental stressAtherosclerosisLeucocyte recruitmentNeuroimmune interactionSympathetic nervous systemVascular inflammationAnimalsAtherosclerosisDisease Models, AnimalEndothelial CellsInflammationMiceMice, Inbred C57BLMice, KnockoutPlaque, Atherosclerotic
PMID: 34279021
PMCID: PMC8516477
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Research group L'influence du rôle du cycle circadien sur l'immunité (995)
European Commission: CIRCODE
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HINTERDOBLER, Julia et al. Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis. In: European heart journal , 2021, vol. 42, n° 39, p. 4077-4088. doi: 10.1093/eurheartj/ehab371 https://archive-ouverte.unige.ch/unige:156530

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Deposited on : 2021-11-18

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