UNIGE document Scientific Article - Letter
previous document  unige:156505  next document
add to browser collection

Circadian clocks guide dendritic cells into skin lymphatics

Holtkamp, Stephan J.
Schmitt, Madeleine T.
Pilorz, Violetta
show hidden authors show all authors [1 - 23]
Published in Nature immunology. 2021, vol. 22, no. 11, p. 1375-1381
Abstract Migration of leukocytes from the skin to lymph nodes (LNs) via afferent lymphatic vessels (LVs) is pivotal for adaptive immune responses 1,2 . Circadian rhythms have emerged as important regulators of leukocyte trafficking to LNs via the blood 3,4 . Here, we demonstrate that dendritic cells (DCs) have a circadian migration pattern into LVs, which peaks during the rest phase in mice. This migration pattern is determined by rhythmic gradients in the expression of the chemokine CCL21 and of adhesion molecules in both mice and humans. Chronopharmacological targeting of the involved factors abrogates circadian migration of DCs. We identify cell-intrinsic circadian oscillations in skin lymphatic endothelial cells (LECs) and DCs that cogovern these rhythms, as their genetic disruption in either cell type ablates circadian trafficking. These observations indicate that circadian clocks control the infiltration of DCs into skin lymphatics, a process that is essential for many adaptive immune responses and relevant for vaccination and immunotherapies.
PMID: 34663979
PMCID: PMC8553624
Full text
Research groups Endocrinologie et horloge circadienne (948)
L'influence du rôle du cycle circadien sur l'immunité (995)
European Commission: CIRCODE
Swiss National Science Foundation: 310030_182417
Swiss National Science Foundation: 310030_184708
(ISO format)
HOLTKAMP, Stephan J. et al. Circadian clocks guide dendritic cells into skin lymphatics. In: Nature immunology , 2021, vol. 22, n° 11, p. 1375-1381. doi: 10.1038/s41590-021-01040-x https://archive-ouverte.unige.ch/unige:156505

135 hits



Deposited on : 2021-11-18

Export document
Format :
Citation style :