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Scientific article
Open access
English

Psychotic experiences in daily-life in adolescents and young adults with 22q11.2 deletion syndrome: An Ecological Momentary Assessment study

Published inSchizophrenia research, vol. 238, p. 54-61
Publication date2021-12
First online date2021-10-01
Abstract

22q11.2 deletion syndrome (22q11DS) is a genetic condition associated with a markedly increased risk for psychosis. Psychotic experiences are classically evaluated by clinical interviews that give little information about these symptoms' fluctuation in daily-life. The current study aims to investigate these phenomena using the Ecological Momentary Assessment (EMA), a structured diary technique that collects real-life measures in the everyday-life context, and to examine how these manifestations relate to a gold standard semi-structured assessment of psychotic experiences. Eighty-six individuals with 22q11DS as well as healthy controls (HC) aged 11-27 years were recruited. They completed a 6-day EMA protocol assessing momentary psychotic experiences as well as positive and negative affect. The presence of (attenuated) psychotic symptoms was assessed in 22q11DS participants with the SIPS interview. Participants with 22q11DS reported more intense (p = .005) and more frequent (p = .006) momentary psy- chotic experiences than HC. Significant associations between negative affect and momentary psychotic experi- ences were observed in both groups (p = .001). In participants with 22q11DS, more intense (p = <.001) and more frequent (p = <.001) momentary psychotic experiences measured by EMA were associated with the severity of SIPS positive symptoms. Participants with 22q11DS reporting at least attenuated positive symptoms of psychosis on the SIPS had more intense (p = .027) and more frequent (p = .023) momentary psychotic expe- riences than participants with 22q11DS without psychotic symptoms. This study highlights the validity of EMA to assess psychotic experiences in the context of daily-life and sets correspondence between EMA and the SIPS. Furthermore, it expands our current understanding of the associ- ations between mood and psychotic experiences.

eng
Keywords
  • 22q11.2 deletion syndrome
  • Psychotic experiences
  • Ecological momentary assessment
  • Positive symptoms
  • Experience sampling method
  • Daily-life assessment
  • Positive and negative affect
Citation (ISO format)
FELLER, Clémence et al. Psychotic experiences in daily-life in adolescents and young adults with 22q11.2 deletion syndrome: An Ecological Momentary Assessment study. In: Schizophrenia research, 2021, vol. 238, p. 54–61. doi: 10.1016/j.schres.2021.09.024
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ISSN of the journal0920-9964
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