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Scientific article
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Effect of Permissive Mild Hypercapnia on Cerebral Vasoreactivity in Infants: A Randomized Controlled Crossover Trial

Published inAnesthesia and Analgesia, vol. 133, no. 4, p. 976-983
Publication date2021
Abstract

Mechanical ventilation interferes with cerebral perfusion via changes in intrathoracic pressure and/or as a consequence of alterations in CO2. Cerebral vascular vasoreactivity is dependent on CO2, and hypocapnia can potentially lead to vasoconstriction and subsequent decrease in cerebral blood flow. Thus, we aimed at characterizing whether protective ventilation with mild permissive hypercapnia improves cerebral perfusion in infants.

Citation (ISO format)
SCHOPFER, Léonore et al. Effect of Permissive Mild Hypercapnia on Cerebral Vasoreactivity in Infants: A Randomized Controlled Crossover Trial. In: Anesthesia and Analgesia, 2021, vol. 133, n° 4, p. 976–983. doi: 10.1213/ANE.0000000000005325
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Creation09/07/2021 8:50:00 PM
First validation09/07/2021 8:50:00 PM
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