Benefit of Physiologically Variable Over Pressure-Controlled Ventilation in a Model of Chronic Obstructive Pulmonary Disease: A Randomized Study

Dos Santos Rocha, André Alexandre; Sudy, Roberta; Bizzotto, Davide; Kassai, Miklos; Carvalho, Tania; Dellacà, Raffaele L; Petak, Ferenc; Habre, Walid

doi:10.3389/fphys.2020.625777

Scientific article

English

Benefit of Physiologically Variable Over Pressure-Controlled Ventilation in a Model of Chronic Obstructive Pulmonary Disease: A Randomized Study

ContributorsDos Santos Rocha, André Alexandre; Sudy, Roberta; Bizzotto, Davide; Kassai, Miklos; Carvalho, Tania; Dellacà, Raffaele L; Petak, Ferenc; Habre, Walid

Published inFrontiers in Physiology, vol. 11, 625777

Publication date2020

Abstract

The advantages of physiologically variable ventilation (PVV) based on a spontaneous breathing pattern have been demonstrated in several respiratory conditions. However, its potential benefits in chronic obstructive pulmonary disease (COPD) have not yet been characterized. We used an experimental model of COPD to compare respiratory function outcomes after 6 h of PVV versus conventional pressure-controlled ventilation (PCV).

Keywords

COPD
Animal model
Gas exchange
Lung mechanics
Variable ventilation

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences

Research groups

Enfants et hyperréactivité bronchique (69)

Funding

Swiss National Science Foundation - Experimental and clinical assessments of the benefit of variable ventilation in diseased lungs [169334]

Citation (ISO format)

DOS SANTOS ROCHA, André Alexandre et al. Benefit of Physiologically Variable Over Pressure-Controlled Ventilation in a Model of Chronic Obstructive Pulmonary Disease: A Randomized Study. In: Frontiers in Physiology, 2020, vol. 11, p. 625777. doi: 10.3389/fphys.2020.625777