Functional neurological disorder (FND) is a core neuropsychiatric condition. To date, promising yet inconsistently identified neural circuit profiles have been observed in patients with FND, suggesting that gaps remain in our systems-level neurobiological understanding. As such, other important physiological variables, including autonomic, endocrine, and inflammation findings, need to be contextualized for a more complete mechanistic picture. The investigators conducted a systematicreview and meta-analysis of available case-control andcohort studies of FND. PubMed, PsycINFO, and Embasedatabases were searched for studies from January 1,1900, to September 1, 2020, that investigated autonomic,endocrine, and inflammation markers in patients withFND. Sixty-six of 2,056 screened records were included inthe review, representing 1,699 patients; data from 20articles were used in the meta-analysis.