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Scientific article
Open access
English

Association between Baseline Cortisol Serum Concentrations and the Effect of Prophylactic Hydrocortisone in Extremely Preterm Infants

Published inThe Journal of Pediatrics, vol. 234, p. 65-70.e3
Publication date2021
Abstract

Objective: To define nomograms of serum cortisol values before 24 hours of postnatal life for extremely preterm infants and determine whether baseline cortisol values affect the benefit/risk ratio of prophylactic hydrocortisone to improve survival without bronchopulmonary dysplasia (BPD). Study design: We performed a predefined secondary analysis of the multicenter randomized controlled PREMILOC trial that included inborn infants delivered before 28 weeks of gestation. Nomograms of baseline serum cortisol values measured in 325 enrolled patients were determined for male and female neonates and correlated to perinatal events. BPD-free survival and severe adverse events were analyzed in placebo and hydrocortisone groups according to the cortisol z score in multivariate logistic regression models.

Keywords
  • Bronchopulmonary dysplasia
  • Hydrocortisone
  • Cortisol
  • Extremely preterm birth
Citation (ISO format)
RENOLLEAU, Chloe et al. Association between Baseline Cortisol Serum Concentrations and the Effect of Prophylactic Hydrocortisone in Extremely Preterm Infants. In: The Journal of Pediatrics, 2021, vol. 234, p. 65–70.e3. doi: 10.1016/j.jpeds.2020.12.057
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Article (Published version)
Identifiers
ISSN of the journal0022-3476
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Technical informations

Creation08/25/2021 9:03:00 AM
First validation08/25/2021 9:03:00 AM
Update time03/16/2023 1:43:19 AM
Status update03/16/2023 1:43:18 AM
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