We read with great interest the systematic review and meta-analysis by Detering et al.1The authors showed that positive path-ological circumferential resection margin (pCRMþ) is an importantrisk factor for increased 3-year and 5-year incidences of local recur-rence, decreased 5-year disease-free survival, decreased 5-yearoverall survival, and increased 5-year incidence of distant metasta-ses.1Therefore, in cases where CRMþis suspected on preoperativepelvic MRI (mrCRMþ), therapeutic management should attempt toinduce local tumor regression using neoadjuvant radiotherapy orchemoradiotherapy.