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Scientific article
English

Enantioselective Synthesis of β-Necrodol and of 1-Epi-β-necrodol via Asymmetric 1,4-Addition and Magnesium-Ene Cyclization. Preliminary Communication

Published inHelvetica chimica acta, vol. 69, no. 8, p. 1817-1820
Publication date1986-12-10
First online date2004-10-25
Abstract

Enantiomerically pure β-necrodol (1) and its 1-epimer 16 have been synthesized starting from aldehyde 5. The two key steps are an asymmetric conjugate addtion/Mannich reaction tandem (10→12) and a type-II-magnesiumene cyclization/oxidation sequence (14→1 + 16).

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Citation (ISO format)
VON OPPOLZER, Wolfgang, SCHNEIDER, Philippe. Enantioselective Synthesis of β-Necrodol and of 1-Epi-β-necrodol via Asymmetric 1,4-Addition and Magnesium-Ene Cyclization. Preliminary Communication. In: Helvetica chimica acta, 1986, vol. 69, n° 8, p. 1817–1820. doi: 10.1002/hlca.19860690805
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ISSN of the journal0018-019X
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