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Scientific article
English

Asymmetric synthesis of ibuprofen via diastereoselective alkylation of a homochiral N-acylbornanesultam

Published inTetrahedron letters, vol. 38, no. 9, p. 1539-1540
Publication date1997-03-03
First online date1998-03-26
Abstract

A very short, 4 step synthesis of 2-(4-isobutylphenyl)propionic acid (ibuprofen) was achieved in 57% overall yield, using a highly diastereoselective alkylation of the chiral enolate derived from N-(4-isobutylphenyl)acetyl bornanesultam as a key step.

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Citation (ISO format)
VON OPPOLZER, Wolfgang, ROSSET, Stéphane, DE BRABANDER, Jef. Asymmetric synthesis of ibuprofen via diastereoselective alkylation of a homochiral N-acylbornanesultam. In: Tetrahedron letters, 1997, vol. 38, n° 9, p. 1539–1540. doi: 10.1016/s0040-4039(97)00148-2
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ISSN of the journal0040-4039
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