Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects
Published inScientific reports, vol. 7, no. 1, 13556
Publication date2017-10-19
First online date2017-10-19
Abstract
Keywords
- Alzheimer Disease / metabolism
- Alzheimer Disease / pathology
- Animals
- Animals, Newborn
- Cerebral Cortex / pathology
- Cerebral Cortex / ultrastructure
- Genetic Vectors / metabolism
- Humans
- Mice
- Mice, Inbred C57BL
- Microtubules / metabolism
- Mutagenesis, Site-Directed
- Neurons / metabolism
- Phosphorylation
- Prosencephalon / metabolism
- Prosencephalon / pathology
- Protein Binding
- Protein Conformation, beta-Strand
- Rotarod Performance Test
- Tau Proteins / genetics
- Tau Proteins / metabolism
Affiliation Not a UNIGE publication
Funding
- European Commission - Promotion of plasticity as a treatment for neurodegenerative conditions [223524]
- Swiss National Science Foundation - Mechanisms of tau proteotoxicity in neurodegeneration [31003A_166612]
- Swiss National Science Foundation - Calcium imaging of cellular and circuit dysfunctions in neurodegeneration [CRSII3_147660]
Citation (ISO format)
LATHUILIERE, Aurélien et al. Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects. In: Scientific reports, 2017, vol. 7, n° 1, p. 13556. doi: 10.1038/s41598-017-13786-2
Main files (1)
Article (Published version)
Secondary files (1)
Identifiers
- PID : unige:155607
- DOI : 10.1038/s41598-017-13786-2
- PMID : 29051562
- PMCID : PMC5648870
ISSN of the journal2045-2322