Remodeling of gap junctions in mouse hearts hypertrophied by forced retinoic acid signaling

van Veen, Toon A B; van Rijen, Harold V M; Wiegerinck, Rob F; Opthof, Tobias; Colbert, Melissa C; Clément Leboube, Sophie; de Bakker, Jacques M T; Jongsma, Habo J

doi:10.1006/jmcc.2002.2102

Scientific article

English

Remodeling of gap junctions in mouse hearts hypertrophied by forced retinoic acid signaling

Contributorsvan Veen, Toon A B; van Rijen, Harold V M; Wiegerinck, Rob F; Opthof, Tobias; Colbert, Melissa C; Clément Leboube, Sophie; de Bakker, Jacques M T; Jongsma, Habo J

Published inJournal of Molecular and Cellular Cardiology, vol. 34, no. 10, p. 1411-1423

Publication date2002

Abstract

Beta-MHC-hRARalpha transgenic mice express a constitutively active (truncated) form of the human retinoic acid receptor which triggers development of dilated cardiomyopathy. In those hearts, we studied expression of gap junction proteins in relation to electrical impulse propagation.

Keywords

Actins/metabolism
Animals
Biomarkers/analysis
Blotting, Western
Body Weight
Cadherins/metabolism
Cardiomegaly/pathology
Connexin 43/metabolism
Cytoskeletal Proteins/metabolism
Down-Regulation
Electric Stimulation
Electrocardiography
Gap Junctions/metabolism
Mice
Mice, Transgenic
Myocardium/pathology
Organ Size
Receptors, Retinoic Acid/genetics/metabolism
Signal Transduction
Trans-Activators/metabolism
Tretinoin/metabolism
beta Catenin

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

Research groups

Etudes et traitement de l'hépatite C et B (554)

Citation (ISO format)

VAN VEEN, Toon A B et al. Remodeling of gap junctions in mouse hearts hypertrophied by forced retinoic acid signaling. In: Journal of Molecular and Cellular Cardiology, 2002, vol. 34, n° 10, p. 1411–1423. doi: 10.1006/jmcc.2002.2102

Article (Published version)

Identifiers

PID : unige:155571
DOI : 10.1006/jmcc.2002.2102
PMID : 12393001

Journal ISSN0022-2828

137views

399downloads

Creation09/06/2021 15:05:00

First validation09/06/2021 15:05:00

Update time16/03/2023 01:33:45

Status update16/03/2023 01:33:45

Last indexation31/10/2024 23:26:44

Archive ouverte UNIGE

Remodeling of gap junctions in mouse hearts hypertrophied by forced retinoic acid signaling

Beta-MHC-hRARalpha transgenic mice express a constitutively active (truncated) form of the human retinoic acid receptor which triggers development of dilated cardiomyopathy. In those hearts, we studied expression of gap junction proteins in relation to electrical impulse propagation.

Technical informations