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Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?

Published inFEBS Letters, vol. 551, no. 1-3, p. 104-106
Publication date2003
Abstract

Intra-myocellular triglycerides (IMTG) accumulate in the muscle of obese and endurance-trained (ET) humans and are considered a pathogenic factor in the development of insulin resistance, in the former. We postulate that this paradox may be associated with the peroxidation status of the IMTG. IMTG content was the same in the obese and ET subjects. The lipid peroxidation/IMTG ratio was 4.2-fold higher in the obese subjects. Hence, obesity results in an increased level of IMTG peroxidation while ET has a protective effect on IMTG peroxidation. This suggests a link between the lipid peroxidation/IMTG ratio and insulin resistance.

Keywords
  • Lipid peroxidation
  • Muscle
  • Obesity
  • Endurance training
  • 4-Hydroxynonenal
  • Intra-myocellular triglyceride
  • IMTG
  • Intra-myocellular triglycerides
  • 4-HNE, 4-hydroxynonenal
  • ET, Endurance-trained
  • ORO, Oil red oil
Citation (ISO format)
RUSSELL, Aaron P et al. Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids? In: FEBS Letters, 2003, vol. 551, n° 1-3, p. 104–106. doi: 10.1016/S0014-5793(03)00875-5
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ISSN of the journal0014-5793
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