Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?

Russell, Aaron P; Gastaldi, Giacomo Gianni Giuseppe; Bobbioni, Maria Elisabetta; Arboit, Patrizia; Gobelet, Charles; Dériaz, Olivier; Golay, Alain; Witztum, Joseph L; Giacobino, Jean-Paul

doi:10.1016/S0014-5793(03)00875-5

Advanced search

Browse by...

Deposit

Highlights

More informations

Title		Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?
Authors		Russell, Aaron P Gastaldi, Giacomo Gianni Giuseppe Bobbioni, Maria Elisabetta Arboit, Patrizia Gobelet, Charles Dériaz, Olivier Golay, Alain Witztum, Joseph L Giacobino, Jean-Paul show all authors [1 - 9]
Published in		FEBS Letters. 2003, vol. 551, no. 1-3, p. 104-106
Abstract		Intra-myocellular triglycerides (IMTG) accumulate in the muscle of obese and endurance-trained (ET) humans and are considered a pathogenic factor in the development of insulin resistance, in the former. We postulate that this paradox may be associated with the peroxidation status of the IMTG. IMTG content was the same in the obese and ET subjects. The lipid peroxidation/IMTG ratio was 4.2-fold higher in the obese subjects. Hence, obesity results in an increased level of IMTG peroxidation while ET has a protective effect on IMTG peroxidation. This suggests a link between the lipid peroxidation/IMTG ratio and insulin resistance.
Keywords		Lipid peroxidation — Muscle — Obesity — Endurance training — 4-Hydroxynonenal — Intra-myocellular triglyceride — IMTG — Intra-myocellular triglycerides — 4-HNE, 4-hydroxynonenal — ET, Endurance-trained — ORO, Oil red oil
Identifiers		DOI: 10.1016/S0014-5793(03)00875-5 PMID: 12965212
Full text		Article (Published version) (138 Kb) - Free access Other version: http://doi.wiley.com/10.1016/S0014-5793%2803%2900875-5
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Citation (ISO format)		RUSSELL, Aaron P et al. Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?. In: FEBS Letters, 2003, vol. 551, n° 1-3, p. 104-106. doi: 10.1016/S0014-5793(03)00875-5 https://archive-ouverte.unige.ch/unige:155544