A population pharmacokinetic model for escitalopram and its major metabolite in depressive patients during the perinatal period: Prediction of infant drug exposure through breast milk

Weisskopf, Etienne; Guidi, Monia; Fischer, Céline J; Bickle Graz, Myriam; Beaufils, Etienne; Nguyen, Kim An; Morisod Harari, Mathilde; Rouiller, Sylvie; Rothenburger, Sophie; Gaucherand, Pascal; Kassai-Koupai, Behrouz; Borradori Tolsa, Cristina; Epiney, Manuela; Tolsa, Jean-François; Vial, Yvan; Hascoët, Jean-Michel; Claris, Olivier; Eap, Chin Bin; Panchaud-Monnat, Alice; Csajka, Chantal

doi:10.1111/bcp.14278

Scientific article

English

A population pharmacokinetic model for escitalopram and its major metabolite in depressive patients during the perinatal period: Prediction of infant drug exposure through breast milk

Published inBritish Journal of Clinical Pharmacology, vol. 86, no. 8, p. 1642-1653

Publication date2020

Abstract

Escitalopram (SCIT) is frequently prescribed to breastfeeding women. Available information on SCIT excretion into breast milk is based on heterogeneous and incomplete data. A population pharmacokinetic model that aimed to better characterize maternal and infant exposure to SCIT and its metabolite was developed.

Keywords

Animals
Breast Feeding
Citalopram/pharmacokinetics
Female
Humans
Infant
Milk
Human/metabolism
Pharmaceutical Preparations
Pregnancy
Prospective Studies
Serotonin Uptake Inhibitors/pharmacokinetics

Affiliation entities

Research groups

Funding

Swiss National Science Foundation - Prediction of infant drug exposure to antidepressant drugs through breastfeeding using population pharmacokinetic modeling and simulation [320030_135650]

Citation (ISO format)

WEISSKOPF, Etienne et al. A population pharmacokinetic model for escitalopram and its major metabolite in depressive patients during the perinatal period: Prediction of infant drug exposure through breast milk. In: British Journal of Clinical Pharmacology, 2020, vol. 86, n° 8, p. 1642–1653. doi: 10.1111/bcp.14278

Article (Published version)

Identifiers

PID : unige:155525
DOI : 10.1111/bcp.14278
PMID : 32162723

Commercial URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373710/

Journal ISSN0306-5251

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Creation07/26/2021 10:01:00 AM

First validation07/26/2021 10:01:00 AM

Update time03/16/2023 1:32:37 AM

Status update03/16/2023 1:32:36 AM

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A population pharmacokinetic model for escitalopram and its major metabolite in depressive patients during the perinatal period: Prediction of infant drug exposure through breast milk

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