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Skin melanoma deaths within 1 or 3 years from diagnosis in Europe

Sacchetto, Lidia
Rosso, Stefano
Comber, Harry
Broganelli, Paolo
Galceran, Jaume
Hackl, Monika
Katalinic, Alexander
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Published in International Journal of Cancer. 2021, vol. 148, no. 12, p. 2898-2905
Abstract The steep increase in incidence of cutaneous malignant melanoma in white populations mainly applies to thin lesions with good survival suggesting overdiagnosis. Based on population-based cancer registries (CRs), we have investigated changes in aggressive melanoma, selecting only cases who died within 1 or 3 years after diagnosis in 11 European countries between 1995 and 2012. Trends in fatal cases were analysed by period of diagnosis, sex, tumour thickness, histologic subtype of the lesion, tumour site and CR with a multivariate generalised linear mixed effects model, where geographical area was considered as a random effect. We collected data on 123 360 invasive melanomas, with 5133 fatal cases at 1 year (4%) and 12 330 (10%) at 3 years. The number of fatal cases showed a 16% decrease at 1 year and 8% at 3 years between the first (1995-2000) and the last (2007-2012) period. The highest proportion of fatal cases was seen for men, older age (≥65 years), thick lesions (>1 mm), nodular melanoma, melanoma on the trunk and for poorly documented cases, lacking information about thickness and histologic subtype. The mixed-effects model showed a remarkable variability among European countries. The majority of registries showed a decreasing trend in fatal cases, but a few registries showed an opposite pattern. Trends in fatal melanoma cases, highlighting real changes in risk not related to overdiagnosis, showed a decrease in most European countries, with a few exceptions. Stronger efforts for early detection could lead to a more efficient treatment of melanoma in general.
Keywords EuropeLethalityMelanomaPrognostic factorsTrendsAdolescentAdultAge FactorsAgedChildChild, PreschoolEurope / epidemiologyFemaleHumansIncidenceInfantInfant, NewbornMaleMelanoma / diagnosisMelanoma / mortalityMelanoma / pathologyMiddle AgedMortality / trendsMultivariate AnalysisRegistriesSex CharacteristicsSkin Neoplasms / diagnosisSkin Neoplasms / mortalitySkin Neoplasms / pathologyYoung Adult
PMID: 33497469
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Research groups Epidémiologie des tumeurs (1017)
Groupe Bouchardy Magnin Christine (Registre genevois des tumeurs) (532)
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SACCHETTO, Lidia et al. Skin melanoma deaths within 1 or 3 years from diagnosis in Europe. In: International journal of cancer , 2021, vol. 148, n° 12, p. 2898-2905. doi: 10.1002/ijc.33479 https://archive-ouverte.unige.ch/unige:155405

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Deposited on : 2021-10-14

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