Scientific article
OA Policy
English

MRI‐guided attenuation correction in torso PET/MRI: Assessment of segmentation‐, atlas‐, and deep learning‐based approaches in the presence of outliers

Published inMagnetic Resonance in Medicine, vol. 87, no. 2, p. 686-701
Publication date2022
Abstract

Purpose: We compare the performance of three commonly used MRI-guided attenuation correction approaches in torso PET/MRI, namely segmentation-, atlas-, and deep learning-based algorithms. Methods: Twenty-five co-registered torso 18F-FDG PET/CT and PET/MR images were enrolled. PET attenuation maps were generated from in-phase Dixon MRI using a three-tissue class segmentation-based approach (soft-tissue, lung, and background air), voxel-wise weighting atlas-based approach, and a residual convolutional neural network. The bias in standardized uptake value (SUV) was calculated for each approach considering CT-based attenuation corrected PET images as reference. In addition to the overall performance assessment of these approaches, the primary focus of this work was on recognizing the origins of potential outliers, notably body truncation, metal-artifacts, abnormal anatomy, and small malignant lesions in the lungs. Results: The deep learning approach outperformed both atlas- and segmentation-based methods resulting in less than 4% SUV bias across 25 patients compared to the segmentation-based method with up to 20% SUV bias in bony structures and the atlas-based method with 9% bias in the lung. The deep learning-based method exhibited superior performance. Yet, in case of sever truncation and metallic-artifacts in the input MRI, this approach was outperformed by the atlas-based method, exhibiting suboptimal performance in the affected regions. Conversely, for abnormal anatomies, such as a patient presenting with one lung or small malignant lesion in the lung, the deep learning algorithm exhibited promising performance compared to other methods. Conclusion: The deep learning-based method provides promising outcome for synthetic CT generation from MRI. However, metal-artifact and body truncation should be specifically addressed.

Keywords
  • Body truncation
  • Deep learning
  • Metal artifact
  • PET/MRI
  • Quantitative PET
Notemettre à jour le pdfhttp://www.hug-ge.ch/sites/interhug/files/structures/pinlab/documents/mrm2022.pdf
Citation (ISO format)
ARABI, Hossein, ZAIDI, Habib. MRI‐guided attenuation correction in torso PET/MRI: Assessment of segmentation‐, atlas‐, and deep learning‐based approaches in the presence of outliers. In: Magnetic Resonance in Medicine, 2022, vol. 87, n° 2, p. 686–701. doi: 10.1002/mrm.29003
Main files (1)
Article (Published version)
Identifiers
Journal ISSN0740-3194
299views
250downloads

Technical informations

Creation04/09/2021 17:06:00
First validation04/09/2021 17:06:00
Update16/03/2023 01:26:30
Status update16/03/2023 01:26:29
Last indexation31/10/2024 23:17:21
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack