Three versus six weeks of antibiotic therapy for diabetic foot osteomyelitis: A prospective, randomized, non-inferiority pilot trial

Gariani, Karim; Pham, Truong-Thanh; Kressmann, Benjamin; Jornayvaz, François; Gastaldi, Giacomo Gianni Giuseppe; Stafylakis, Dimitrios; Philippe, Jacques; Lipsky, Benjamin Alan; Uckay, Ilker

doi:10.1093/cid/ciaa1758

Scientific article

English

Three versus six weeks of antibiotic therapy for diabetic foot osteomyelitis: A prospective, randomized, non-inferiority pilot trial

ContributorsGariani, Karim; Pham, Truong-Thanh

; Kressmann, Benjamin; Jornayvaz, François

; Gastaldi, Giacomo Gianni Giuseppe

; Stafylakis, Dimitrios; Philippe, Jacques; Lipsky, Benjamin Alan; Uckay, Ilker

Published inClinical Infectious Diseases

Publication date2020

Abstract

In patients with diabetic foot osteomyelitis (DFO) who underwent surgical debridement, we investigated whether a short (3 weeks), compared with a long (6 weeks) duration of systemic antibiotic treatment is associated with non-inferior results for clinical remission and adverse events (AE).

Keywords

Diabetic foot osteomyelitis
Antibiotic duration
Infection remission
Adverse events
Randomized-controlled pilot trial

Affiliation entities

Research groups

MASLD/MASH et résistance à l'insuline (997)

Funding

Autre - Fondation pour la lutte contre le cancer et pour les recherches médico-biologiques

Citation (ISO format)

GARIANI, Karim et al. Three versus six weeks of antibiotic therapy for diabetic foot osteomyelitis: A prospective, randomized, non-inferiority pilot trial. In: Clinical Infectious Diseases, 2020. doi: 10.1093/cid/ciaa1758

Article (Accepted version)

Article (Published version)

Appendix

Identifiers

PID : unige:155162
DOI : 10.1093/cid/ciaa1758
PMID : 33242083

Journal ISSN1058-4838

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Creation23/03/2021 11:13:00

First validation23/03/2021 11:13:00

Update06/01/2025 08:24:56

Status update06/01/2025 08:24:56

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Three versus six weeks of antibiotic therapy for diabetic foot osteomyelitis: A prospective, randomized, non-inferiority pilot trial

In patients with diabetic foot osteomyelitis (DFO) who underwent surgical debridement, we investigated whether a short (3 weeks), compared with a long (6 weeks) duration of systemic antibiotic treatment is associated with non-inferior results for clinical remission and adverse events (AE).

Technical informations