en
Scientific article
English

Brain accumulation of inhaled uranium in the rat depends on aerosol concentration, exposure repetitions, particle size and solubility

Published inToxicology letters, vol. 351, p. 10-17
Publication date2021-10
First online date2021-08-05
Abstract

A rostro-caudal gradient of uranium (U) in the brain has been suggested after its inhalation. To study the factors influencing this mapping, we first used 30-min acute inhalation at 56 mg/m3of the relatively soluble form UO4in the rat. These exposure parameters were then used as a reference in comparison with the other experimental conditions. Other groups received acute inhalation at different concentrations, repeated low dose inhalation of UO4(10 exposures) or acute low dose inhalation of the insoluble form UO2. At 24 h after the last exposure, all rats showed a brain U accumulation with a rostro-caudal gradient as compared to controls. However, the total concentration to the brain was greater after repeated exposure than acute exposure, demonstrating an accumulative effect. In comparison with the low dose soluble U exposure, a higher accumulation in the front of the brain was observed after exposure to higher dose, to insoluble particles and following repetition of exposures, thus demonstrating a dose effect and influences of solubility and repetition of exposures. In the last part, exposure to ultrafine U particles made it possible to show 24 h after exposure the presence of U in the brain according to a rostro-caudal gradient. Finally, the time-course after exposure to micronic or nanometric U particles has revealed greater residence times for nanoparticles.

eng
Keywords
  • Inhalation
  • Nanoparticles
  • Rat
  • Solubility
  • Uranium
Citation (ISO format)
TOURNIER, Benjamin et al. Brain accumulation of inhaled uranium in the rat depends on aerosol concentration, exposure repetitions, particle size and solubility. In: Toxicology letters, 2021, vol. 351, p. 10–17. doi: 10.1016/j.toxlet.2021.08.002
Main files (1)
Article (Published version)
accessLevelRestricted
Secondary files (1)
Identifiers
ISSN of the journal0378-4274
141views
0downloads

Technical informations

Creation09/25/2021 7:40:00 AM
First validation09/25/2021 7:40:00 AM
Update time03/16/2023 1:24:09 AM
Status update03/16/2023 1:24:08 AM
Last indexation01/29/2024 10:45:27 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack